The clinical problem of occult cardiac amyloidosis

Forensic implications

E. C. Petersen, J. A. Engel, Stanley J Radio, T. M. Canfield, B. M. McManus

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A 68-year-old man with known coronary heart disease experienced rapidly progressive cardiac dysfunction and was found to have occult cardiac amyloidosis at autopsy. The amyloidosis was undiagnosed during life and initially at autopsy. Marked diffuse involvement of the intramural coronary arteries by amyloid deposits resulted in severe luminal compromise of numerous medium and small vessels. The myocardium proper was virtually spared from amyloid deposits. Amyloid-related coronary narrowing contributed to cardiac ischemia and sudden death. The significance of amyloid coronary disease in this patient relates primarily to the difficulty in considering the diagnosis when other reasons for cardiac signs and symptoms preexist. Also, the adverse effects of amyloid coronary disease may be profound without direct myocardial involvement.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalAmerican Journal of Forensic Medicine and Pathology
Volume13
Issue number3
DOIs
StatePublished - Jan 1 1992

Fingerprint

Amyloidosis
Amyloid
Coronary Disease
Amyloid Plaques
Disease
Autopsy
heart disease
compromise
Sudden Cardiac Death
death
Signs and Symptoms
Coronary Vessels
Myocardium
Ischemia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The clinical problem of occult cardiac amyloidosis : Forensic implications. / Petersen, E. C.; Engel, J. A.; Radio, Stanley J; Canfield, T. M.; McManus, B. M.

In: American Journal of Forensic Medicine and Pathology, Vol. 13, No. 3, 01.01.1992, p. 225-229.

Research output: Contribution to journalArticle

Petersen, E. C. ; Engel, J. A. ; Radio, Stanley J ; Canfield, T. M. ; McManus, B. M. / The clinical problem of occult cardiac amyloidosis : Forensic implications. In: American Journal of Forensic Medicine and Pathology. 1992 ; Vol. 13, No. 3. pp. 225-229.
@article{383a1f0e38714e0e8f58f175fbd00db3,
title = "The clinical problem of occult cardiac amyloidosis: Forensic implications",
abstract = "A 68-year-old man with known coronary heart disease experienced rapidly progressive cardiac dysfunction and was found to have occult cardiac amyloidosis at autopsy. The amyloidosis was undiagnosed during life and initially at autopsy. Marked diffuse involvement of the intramural coronary arteries by amyloid deposits resulted in severe luminal compromise of numerous medium and small vessels. The myocardium proper was virtually spared from amyloid deposits. Amyloid-related coronary narrowing contributed to cardiac ischemia and sudden death. The significance of amyloid coronary disease in this patient relates primarily to the difficulty in considering the diagnosis when other reasons for cardiac signs and symptoms preexist. Also, the adverse effects of amyloid coronary disease may be profound without direct myocardial involvement.",
author = "Petersen, {E. C.} and Engel, {J. A.} and Radio, {Stanley J} and Canfield, {T. M.} and McManus, {B. M.}",
year = "1992",
month = "1",
day = "1",
doi = "10.1097/00000433-199209000-00012",
language = "English (US)",
volume = "13",
pages = "225--229",
journal = "American Journal of Forensic Medicine and Pathology",
issn = "0195-7910",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - The clinical problem of occult cardiac amyloidosis

T2 - Forensic implications

AU - Petersen, E. C.

AU - Engel, J. A.

AU - Radio, Stanley J

AU - Canfield, T. M.

AU - McManus, B. M.

PY - 1992/1/1

Y1 - 1992/1/1

N2 - A 68-year-old man with known coronary heart disease experienced rapidly progressive cardiac dysfunction and was found to have occult cardiac amyloidosis at autopsy. The amyloidosis was undiagnosed during life and initially at autopsy. Marked diffuse involvement of the intramural coronary arteries by amyloid deposits resulted in severe luminal compromise of numerous medium and small vessels. The myocardium proper was virtually spared from amyloid deposits. Amyloid-related coronary narrowing contributed to cardiac ischemia and sudden death. The significance of amyloid coronary disease in this patient relates primarily to the difficulty in considering the diagnosis when other reasons for cardiac signs and symptoms preexist. Also, the adverse effects of amyloid coronary disease may be profound without direct myocardial involvement.

AB - A 68-year-old man with known coronary heart disease experienced rapidly progressive cardiac dysfunction and was found to have occult cardiac amyloidosis at autopsy. The amyloidosis was undiagnosed during life and initially at autopsy. Marked diffuse involvement of the intramural coronary arteries by amyloid deposits resulted in severe luminal compromise of numerous medium and small vessels. The myocardium proper was virtually spared from amyloid deposits. Amyloid-related coronary narrowing contributed to cardiac ischemia and sudden death. The significance of amyloid coronary disease in this patient relates primarily to the difficulty in considering the diagnosis when other reasons for cardiac signs and symptoms preexist. Also, the adverse effects of amyloid coronary disease may be profound without direct myocardial involvement.

UR - http://www.scopus.com/inward/record.url?scp=0026728066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026728066&partnerID=8YFLogxK

U2 - 10.1097/00000433-199209000-00012

DO - 10.1097/00000433-199209000-00012

M3 - Article

VL - 13

SP - 225

EP - 229

JO - American Journal of Forensic Medicine and Pathology

JF - American Journal of Forensic Medicine and Pathology

SN - 0195-7910

IS - 3

ER -