The choice of a constitutive formulation for modeling limb flexion-induced deformations and stresses in the human femoropopliteal arteries of different ages

Anastasia Desyatova, Jason N Mactaggart, William Poulson, Paul Deegan, Carol Lomneth, Anjali Sandip, Alexey Kamenskiy

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Open and endovascular treatments for peripheral arterial disease are notorious for high failure rates. Severe mechanical deformations experienced by the femoropopliteal artery (FPA) during limb flexion and interactions between the artery and repair materials play important roles and may contribute to poor clinical outcomes. Computational modeling can help optimize FPA repair, but these simulations heavily depend on the choice of constitutive model describing the arterial behavior. In this study finite element model of the FPA in the standing (straight) and gardening (acutely bent) postures was built using computed tomography data, longitudinal pre-stretch and biaxially determined mechanical properties. Springs and dashpots were used to represent surrounding tissue forces associated with limb flexion-induced deformations. These forces were then used with age-specific longitudinal pre-stretch and mechanical properties to obtain deformed FPA configurations for seven age groups. Four commonly used invariant-based constitutive models were compared to determine the accuracy of capturing deformations and stresses in each age group. The four-fiber FPA model most accurately portrayed arterial behavior in all ages, but in subjects younger than 40 years, the performance of all constitutive formulations was similar. In older subjects, Demiray (Delfino) and classic two-fiber Holzapfel–Gasser–Ogden formulations were better than the Neo-Hookean model for predicting deformations due to limb flexion, but both significantly overestimated principal stresses compared to the FPA or Neo-Hookean models.

Original languageEnglish (US)
Pages (from-to)775-785
Number of pages11
JournalBiomechanics and Modeling in Mechanobiology
Volume16
Issue number3
DOIs
StatePublished - Jun 1 2017

Fingerprint

Arteries
Extremities
Formulation
Constitutive models
Modeling
Repair
Mechanical properties
Constitutive Model
Stretch
Fibers
Mechanical Properties
Tomography
Age Groups
Gardening
Fiber
Tissue
Computational Modeling
Peripheral Arterial Disease
Computed Tomography
Failure Rate

Keywords

  • Constitutive model
  • Femoropopliteal artery
  • Finite element modeling
  • Limb flexion

ASJC Scopus subject areas

  • Biotechnology
  • Modeling and Simulation
  • Mechanical Engineering

Cite this

The choice of a constitutive formulation for modeling limb flexion-induced deformations and stresses in the human femoropopliteal arteries of different ages. / Desyatova, Anastasia; Mactaggart, Jason N; Poulson, William; Deegan, Paul; Lomneth, Carol; Sandip, Anjali; Kamenskiy, Alexey.

In: Biomechanics and Modeling in Mechanobiology, Vol. 16, No. 3, 01.06.2017, p. 775-785.

Research output: Contribution to journalArticle

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