The chemokine receptor CCR6 is an important component of the innate immune response

Haitao Wen, Cory M. Hogaboam, Nicholas W. Lukacs, Donald N. Cook, Sergio A. Lira, Steven L. Kunkel

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In our initial studies we found that naïve CCR6-deficient (CCR6-/ -) C57BL/6 mice possessed significantly lower number of both F4/80+ macrophages and dendritic cells (DC), but higher number of B cells in the peritoneal cavity, as compared to naïve wild type (WT) controls. Furthermore, peritoneal macrophages isolated from CCR6-/- mice expressed significantly lower levels of inflammatory cytokines and nitric oxide following lipopolysaccharide (LPS) stimulation, as compared to WT macrophages. In a severe experimental peritonitis model induced by cecal ligation and puncture (CLP), CCR6-/- mice were protected when compared with WT controls. At 24 h following the induction of peritonitis, CCR6-/- mice exhibited significantly lower levels of inflammatory cytokines/chemokines in both the peritoneal cavity and blood. Interestingly, DC recruitment into the peritoneal cavity was impaired in CCR6-/- mice during the evolution of CLP-induced peritonitis. Peritoneal macrophages isolated from surviving CCR6-/- mice 3 days after CLP-induced peritonitis exhibited an enhanced LPS response compared with similarly treated WT peritoneal macrophages. These data illustrate that CCR6 deficiency alters the innate response via attenuating the hyperactive local and systemic inflammatory response during CLP-induced peritonitis.

Original languageEnglish (US)
Pages (from-to)2487-2498
Number of pages12
JournalEuropean Journal of Immunology
Volume37
Issue number9
DOIs
StatePublished - Sep 1 2007

Fingerprint

Chemokine Receptors
Peritonitis
Innate Immunity
Punctures
Ligation
Peritoneal Cavity
Peritoneal Macrophages
Dendritic Cells
Lipopolysaccharides
Macrophages
Cytokines
Inbred C57BL Mouse
Chemokines
Nitric Oxide
B-Lymphocytes
Theoretical Models
Cell Count

Keywords

  • Chemokine
  • Macrophage
  • Sepsis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Wen, H., Hogaboam, C. M., Lukacs, N. W., Cook, D. N., Lira, S. A., & Kunkel, S. L. (2007). The chemokine receptor CCR6 is an important component of the innate immune response. European Journal of Immunology, 37(9), 2487-2498. https://doi.org/10.1002/eji.200737370

The chemokine receptor CCR6 is an important component of the innate immune response. / Wen, Haitao; Hogaboam, Cory M.; Lukacs, Nicholas W.; Cook, Donald N.; Lira, Sergio A.; Kunkel, Steven L.

In: European Journal of Immunology, Vol. 37, No. 9, 01.09.2007, p. 2487-2498.

Research output: Contribution to journalArticle

Wen, H, Hogaboam, CM, Lukacs, NW, Cook, DN, Lira, SA & Kunkel, SL 2007, 'The chemokine receptor CCR6 is an important component of the innate immune response', European Journal of Immunology, vol. 37, no. 9, pp. 2487-2498. https://doi.org/10.1002/eji.200737370
Wen, Haitao ; Hogaboam, Cory M. ; Lukacs, Nicholas W. ; Cook, Donald N. ; Lira, Sergio A. ; Kunkel, Steven L. / The chemokine receptor CCR6 is an important component of the innate immune response. In: European Journal of Immunology. 2007 ; Vol. 37, No. 9. pp. 2487-2498.
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