Abstract

This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Geoffrey M. Thiele and Simon Worrall. The presentations were (1) The chemistry of malondialdehyde-acetaldehyde (MAA) adducts, by Dean J. Tuma; (2) The formation and clearance of MAA adducts in ethanol-fed rats, by Simon Worrall; (3) Immune responses to MAA adducts may play a role in the development of alcoholic liver disease, by Lynell W. Klassen; (4) Unique biological responses to MAA-modified proteins that may play a role in the development and/or progression of alcoholic liver disease, by Geoffrey M. Thiele; (5) MAA-adducted bovine serum albumin activates protein kinase C and stimulates interleukin-8 release in bovine bronchial epithelial cells, by Todd A. Wyatt; and (6) An enzyme immune assay for serum antiacetaldehyde adduct antibody using low-density lipoprotein-adduct and its significance in alcoholic liver injury and ALDH2 heterozygotes, by Naruhiko Nagata.

Original languageEnglish (US)
JournalAlcoholism: Clinical and Experimental Research
Volume25
Issue number5 SUPPL.
StatePublished - Jun 27 2001

Fingerprint

Acetaldehyde
Malondialdehyde
Liver
Alcoholic Liver Diseases
Enzyme Assays
Heterozygote
Bovine Serum Albumin
Interleukin-8
LDL Lipoproteins
Protein Kinase C
Rats
Immune Sera
Assays
Japan
Ethanol
Epithelial Cells
Education
Antibodies
Wounds and Injuries
Enzymes

Keywords

  • Alcoholic Liver Disease
  • Ethanol
  • Malondialdehyde-Acetaldehyde
  • Protein Kinase C
  • Rats

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

The chemistry and biological effects of malondialdehyde-acetaldehyde adducts. / Thiele, Geoffrey Milton; Worrall, S.; Tuma, D. J.; Klassen, Lynell Warren; Wyatt, Todd A; Nagata, N.

In: Alcoholism: Clinical and Experimental Research, Vol. 25, No. 5 SUPPL., 27.06.2001.

Research output: Contribution to journalArticle

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