The Cbl protooncoprotein: A negative regulator of immune receptor signal transduction

Mark L. Lupher, Navin Rao, Michael J. Eck, Hamid Band

Research output: Contribution to journalReview article

121 Citations (Scopus)

Abstract

The Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-mediated signal transduction in a variety of cell types. Here, we discuss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.

Original languageEnglish (US)
Pages (from-to)375-382
Number of pages8
JournalImmunology Today
Volume20
Issue number8
DOIs
StatePublished - Aug 1 1999

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Protein-Tyrosine Kinases
Signal Transduction

ASJC Scopus subject areas

  • Immunology

Cite this

The Cbl protooncoprotein : A negative regulator of immune receptor signal transduction. / Lupher, Mark L.; Rao, Navin; Eck, Michael J.; Band, Hamid.

In: Immunology Today, Vol. 20, No. 8, 01.08.1999, p. 375-382.

Research output: Contribution to journalReview article

Lupher, Mark L. ; Rao, Navin ; Eck, Michael J. ; Band, Hamid. / The Cbl protooncoprotein : A negative regulator of immune receptor signal transduction. In: Immunology Today. 1999 ; Vol. 20, No. 8. pp. 375-382.
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