The Cbl protooncoprotein: A negative regulator of immune receptor signal transduction

Mark L. Lupher, Navin Rao, Michael J. Eck, Hamid Band

Research output: Contribution to journalReview article

121 Scopus citations


The Cbl protooncoprotein has recently emerged as a component of tyrosine kinase-mediated signal transduction in a variety of cell types. Here, we discuss evidence that supports a role for Cbl as a novel negative regulator of immune receptor signaling, and present models for its mode of function.

Original languageEnglish (US)
Pages (from-to)375-382
Number of pages8
JournalImmunology Today
Issue number8
StatePublished - Aug 1 1999


ASJC Scopus subject areas

  • Immunology

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