The capsaicinoids: Their separation, synthesis, and mutagenicity

Peter M. Gannett, Donald L. Nagel, Pam J. Reilly, Terence Lawson, Jody Sharpe, Bela Toth

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

Capsaicin (1b), the pungent ingredient in many varieties of Capsicums has recently been implicated as a possible carcinogen. When obtained from natural sources 1b is always accompanied by a number of related homologues. We have isolated seven of these homologues, characterized them, and synthesized them by a general and unique route developed in our laboratories. Also reported are mutagenicity data for lb and an extract of red pepper as measured by the Ames assay and the V-79 mammalian cell assay.

Original languageEnglish (US)
Pages (from-to)1064-1071
Number of pages8
JournalJournal of Organic Chemistry
Volume53
Issue number5
DOIs
Publication statusPublished - Mar 1 1988

    Fingerprint

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Gannett, P. M., Nagel, D. L., Reilly, P. J., Lawson, T., Sharpe, J., & Toth, B. (1988). The capsaicinoids: Their separation, synthesis, and mutagenicity. Journal of Organic Chemistry, 53(5), 1064-1071. https://doi.org/10.1021/jo00240a024