The capsaicinoids: Their separation, synthesis, and mutagenicity

Peter M. Gannett, Donald L. Nagel, Pam J. Reilly, Terence Lawson, Jody Sharpe, Bela Toth

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Capsaicin (1b), the pungent ingredient in many varieties of Capsicums has recently been implicated as a possible carcinogen. When obtained from natural sources 1b is always accompanied by a number of related homologues. We have isolated seven of these homologues, characterized them, and synthesized them by a general and unique route developed in our laboratories. Also reported are mutagenicity data for lb and an extract of red pepper as measured by the Ames assay and the V-79 mammalian cell assay.

Original languageEnglish (US)
Pages (from-to)1064-1071
Number of pages8
JournalJournal of Organic Chemistry
Volume53
Issue number5
DOIs
StatePublished - Mar 1 1988

Fingerprint

Assays
Capsaicin
Carcinogens
Cells

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Gannett, P. M., Nagel, D. L., Reilly, P. J., Lawson, T., Sharpe, J., & Toth, B. (1988). The capsaicinoids: Their separation, synthesis, and mutagenicity. Journal of Organic Chemistry, 53(5), 1064-1071. https://doi.org/10.1021/jo00240a024

The capsaicinoids : Their separation, synthesis, and mutagenicity. / Gannett, Peter M.; Nagel, Donald L.; Reilly, Pam J.; Lawson, Terence; Sharpe, Jody; Toth, Bela.

In: Journal of Organic Chemistry, Vol. 53, No. 5, 01.03.1988, p. 1064-1071.

Research output: Contribution to journalArticle

Gannett, PM, Nagel, DL, Reilly, PJ, Lawson, T, Sharpe, J & Toth, B 1988, 'The capsaicinoids: Their separation, synthesis, and mutagenicity', Journal of Organic Chemistry, vol. 53, no. 5, pp. 1064-1071. https://doi.org/10.1021/jo00240a024
Gannett PM, Nagel DL, Reilly PJ, Lawson T, Sharpe J, Toth B. The capsaicinoids: Their separation, synthesis, and mutagenicity. Journal of Organic Chemistry. 1988 Mar 1;53(5):1064-1071. https://doi.org/10.1021/jo00240a024
Gannett, Peter M. ; Nagel, Donald L. ; Reilly, Pam J. ; Lawson, Terence ; Sharpe, Jody ; Toth, Bela. / The capsaicinoids : Their separation, synthesis, and mutagenicity. In: Journal of Organic Chemistry. 1988 ; Vol. 53, No. 5. pp. 1064-1071.
@article{59441a4ace734ec4be98a96cdcef82ce,
title = "The capsaicinoids: Their separation, synthesis, and mutagenicity",
abstract = "Capsaicin (1b), the pungent ingredient in many varieties of Capsicums has recently been implicated as a possible carcinogen. When obtained from natural sources 1b is always accompanied by a number of related homologues. We have isolated seven of these homologues, characterized them, and synthesized them by a general and unique route developed in our laboratories. Also reported are mutagenicity data for lb and an extract of red pepper as measured by the Ames assay and the V-79 mammalian cell assay.",
author = "Gannett, {Peter M.} and Nagel, {Donald L.} and Reilly, {Pam J.} and Terence Lawson and Jody Sharpe and Bela Toth",
year = "1988",
month = "3",
day = "1",
doi = "10.1021/jo00240a024",
language = "English (US)",
volume = "53",
pages = "1064--1071",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "5",

}

TY - JOUR

T1 - The capsaicinoids

T2 - Their separation, synthesis, and mutagenicity

AU - Gannett, Peter M.

AU - Nagel, Donald L.

AU - Reilly, Pam J.

AU - Lawson, Terence

AU - Sharpe, Jody

AU - Toth, Bela

PY - 1988/3/1

Y1 - 1988/3/1

N2 - Capsaicin (1b), the pungent ingredient in many varieties of Capsicums has recently been implicated as a possible carcinogen. When obtained from natural sources 1b is always accompanied by a number of related homologues. We have isolated seven of these homologues, characterized them, and synthesized them by a general and unique route developed in our laboratories. Also reported are mutagenicity data for lb and an extract of red pepper as measured by the Ames assay and the V-79 mammalian cell assay.

AB - Capsaicin (1b), the pungent ingredient in many varieties of Capsicums has recently been implicated as a possible carcinogen. When obtained from natural sources 1b is always accompanied by a number of related homologues. We have isolated seven of these homologues, characterized them, and synthesized them by a general and unique route developed in our laboratories. Also reported are mutagenicity data for lb and an extract of red pepper as measured by the Ames assay and the V-79 mammalian cell assay.

UR - http://www.scopus.com/inward/record.url?scp=0023865490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023865490&partnerID=8YFLogxK

U2 - 10.1021/jo00240a024

DO - 10.1021/jo00240a024

M3 - Article

AN - SCOPUS:0023865490

VL - 53

SP - 1064

EP - 1071

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 5

ER -