The C-terminal domain of the DNA polymerase catalytic subunit regulates the primase and polymerase activities of the human DNA polymerase α-primase complex

Yinbo Zhang, Andrey G. Baranovskiy, Tahir H Tahirov, Youri I Pavlov

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: DNA polymerase α-primase synthesizes chimeric RNA/DNA primers for replicative polymerases. Results: We defined elements that modulate polα and prim activities. Conclusion: The C-terminal domain of the catalytic subunit of polymerase α and the B-subunit regulate the priming of DNA replication. Significance: We provide new information on the regulation of RNA/DNA synthesizing complex that is indispensable for replication in eukaryotes.

Original languageEnglish (US)
Pages (from-to)22021-22034
Number of pages14
JournalJournal of Biological Chemistry
Volume289
Issue number32
DOIs
StatePublished - Aug 8 2014

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DNA Primase
DNA Primers
DNA-Directed DNA Polymerase
Eukaryota
DNA Replication
Human Activities
Catalytic Domain
RNA
DNA
RNA primers

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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