The butyrylcholinesterase knockout mouse is obese on a high-fat diet

Bin Li, Ellen G. Duysen, Oksana Lockridge

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Butyrylcholinesterase (BChE) inactivates the appetite stimulating hormone octanoyl-ghrelin. The hypothesis was tested that BChE-/- mice would have abnormally high body weight and high levels of octanoyl-ghrelin. It was found that BChE-/- mice fed a standard 5% fat diet had normal body weight. However, BChE-/- mice fed a diet containing 11% fat became obese. Their obesity was not explained by increased levels of octanoyl-ghrelin, or by increased caloric intake, or by decreased exercise. Instead, a role for BChE in fat utilization was suggested.

Original languageEnglish (US)
Pages (from-to)88-91
Number of pages4
JournalChemico-Biological Interactions
Volume175
Issue number1-3
DOIs
StatePublished - Sep 25 2008

Fingerprint

Butyrylcholinesterase
High Fat Diet
Nutrition
Knockout Mice
Fats
Ghrelin
Diet
Ideal Body Weight
Appetite
Energy Intake
Obesity
Body Weight
Hormones

Keywords

  • Butyrylcholinesterase knockout mice
  • Ghrelin
  • Obesity

ASJC Scopus subject areas

  • Toxicology

Cite this

The butyrylcholinesterase knockout mouse is obese on a high-fat diet. / Li, Bin; Duysen, Ellen G.; Lockridge, Oksana.

In: Chemico-Biological Interactions, Vol. 175, No. 1-3, 25.09.2008, p. 88-91.

Research output: Contribution to journalArticle

@article{ac30e6c7f87844d883d71e99997721b2,
title = "The butyrylcholinesterase knockout mouse is obese on a high-fat diet",
abstract = "Butyrylcholinesterase (BChE) inactivates the appetite stimulating hormone octanoyl-ghrelin. The hypothesis was tested that BChE-/- mice would have abnormally high body weight and high levels of octanoyl-ghrelin. It was found that BChE-/- mice fed a standard 5{\%} fat diet had normal body weight. However, BChE-/- mice fed a diet containing 11{\%} fat became obese. Their obesity was not explained by increased levels of octanoyl-ghrelin, or by increased caloric intake, or by decreased exercise. Instead, a role for BChE in fat utilization was suggested.",
keywords = "Butyrylcholinesterase knockout mice, Ghrelin, Obesity",
author = "Bin Li and Duysen, {Ellen G.} and Oksana Lockridge",
year = "2008",
month = "9",
day = "25",
doi = "10.1016/j.cbi.2008.03.009",
language = "English (US)",
volume = "175",
pages = "88--91",
journal = "Chemico-Biological Interactions",
issn = "0009-2797",
publisher = "Elsevier Ireland Ltd",
number = "1-3",

}

TY - JOUR

T1 - The butyrylcholinesterase knockout mouse is obese on a high-fat diet

AU - Li, Bin

AU - Duysen, Ellen G.

AU - Lockridge, Oksana

PY - 2008/9/25

Y1 - 2008/9/25

N2 - Butyrylcholinesterase (BChE) inactivates the appetite stimulating hormone octanoyl-ghrelin. The hypothesis was tested that BChE-/- mice would have abnormally high body weight and high levels of octanoyl-ghrelin. It was found that BChE-/- mice fed a standard 5% fat diet had normal body weight. However, BChE-/- mice fed a diet containing 11% fat became obese. Their obesity was not explained by increased levels of octanoyl-ghrelin, or by increased caloric intake, or by decreased exercise. Instead, a role for BChE in fat utilization was suggested.

AB - Butyrylcholinesterase (BChE) inactivates the appetite stimulating hormone octanoyl-ghrelin. The hypothesis was tested that BChE-/- mice would have abnormally high body weight and high levels of octanoyl-ghrelin. It was found that BChE-/- mice fed a standard 5% fat diet had normal body weight. However, BChE-/- mice fed a diet containing 11% fat became obese. Their obesity was not explained by increased levels of octanoyl-ghrelin, or by increased caloric intake, or by decreased exercise. Instead, a role for BChE in fat utilization was suggested.

KW - Butyrylcholinesterase knockout mice

KW - Ghrelin

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=50649114884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50649114884&partnerID=8YFLogxK

U2 - 10.1016/j.cbi.2008.03.009

DO - 10.1016/j.cbi.2008.03.009

M3 - Article

C2 - 18452903

AN - SCOPUS:50649114884

VL - 175

SP - 88

EP - 91

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

SN - 0009-2797

IS - 1-3

ER -