The BCL6-associated transcriptional co-repressor, MTA3, is selectively expressed by germinal centre B cells and lymphomas of putative germinal centre derivation

D. L. Jaye, Javeed Iqbal, N. Fujita, C. M. Geigerman, S. Li, S. Karanam, Kai Fu, D. D. Weisenburger, W. C. Chan, C. S. Moreno, P. A. Wade

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Metastasis-associated protein 3 (MTA3) is a recently described cell-type specific component of the Mi-2-NURD transcriptional co-repressor complex that is expressed in breast epithelia and germinal centre B cells. In model B cell lines, MTA3 physically interacts with BCL6 and appears to be instrumental in maintenance of the germinal centre B cell transcriptional programme that precludes premature plasmacytic differentiation. Here, we report selective, in situ cell-type specific expression of MTA3 among lymphoid cells largely confined to the germinal centre B cell compartment. Centroblasts display greater expression than smaller, less proliferative centrocytes, with undetectable expression in quiescent plasma cells. Among B cell neoplasms, germinal centre B cell-like lymphomas likewise exhibit selective expression that generally escalates with increasing proliferative capacity. MTA3 protein expression was, in accord, highly predictive of the germinal centre B cell-like gene expression profile for diffuse large B cell lymphomas. Lastly, relative repression of a subset of known BCL6 targets, including BLIMP1 and p27kip1, was highest in diffuse large B cell lymphomas that co-expressed both MTA3 and BCL6 protein. Together, these novel data suggest a role for MTA3 in BCL6-mediated lymphomagenesis in germinal centre B cell-like neoplasms.

Original languageEnglish (US)
Pages (from-to)106-115
Number of pages10
JournalJournal of Pathology
Volume213
Issue number1
DOIs
StatePublished - Sep 1 2007

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Co-Repressor Proteins
Germinal Center
B-Cell Lymphoma
B-Lymphocytes
Neoplasm Metastasis
Proteins
Lymphoma, Large B-Cell, Diffuse
Cellular Structures
Plasma Cells
Transcriptome
Neoplasms
Breast
Epithelium
Maintenance
Lymphocytes
Cell Line

Keywords

  • Gene expression profiling
  • Haematolymphoid organs
  • Immunostaining
  • Lymphoid neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The BCL6-associated transcriptional co-repressor, MTA3, is selectively expressed by germinal centre B cells and lymphomas of putative germinal centre derivation. / Jaye, D. L.; Iqbal, Javeed; Fujita, N.; Geigerman, C. M.; Li, S.; Karanam, S.; Fu, Kai; Weisenburger, D. D.; Chan, W. C.; Moreno, C. S.; Wade, P. A.

In: Journal of Pathology, Vol. 213, No. 1, 01.09.2007, p. 106-115.

Research output: Contribution to journalArticle

Jaye, D. L. ; Iqbal, Javeed ; Fujita, N. ; Geigerman, C. M. ; Li, S. ; Karanam, S. ; Fu, Kai ; Weisenburger, D. D. ; Chan, W. C. ; Moreno, C. S. ; Wade, P. A. / The BCL6-associated transcriptional co-repressor, MTA3, is selectively expressed by germinal centre B cells and lymphomas of putative germinal centre derivation. In: Journal of Pathology. 2007 ; Vol. 213, No. 1. pp. 106-115.
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