The Audiometric and Mechanical Effects of Partial Ossicular Discontinuity

Rosemary B. Farahmand, Gabrielle R. Merchant, Sarah A. Lookabaugh, Christof Röösli, Cagatay H. Ulku, Michael J. McKenna, Ronald K. De Venecia, Christopher F. Halpin, John J. Rosowski, Hideko H. Nakajima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: Ossicular discontinuity may be complete, with no contact between the disconnected ends, or partial, where normal contact at an ossicular joint or along a continuous bony segment of an ossicle is replaced by soft tissue or simply by contact of opposing bones. Complete ossicular discontinuity typically results in an audiometric pattern of a large, flat conductive hearing loss. In contrast, in cases where otomicroscopy reveals a normal external ear canal and tympanic membrane, high-frequency conductive hearing loss has been proposed as an indicator of partial ossicular discontinuity. Nevertheless, the diagnostic utility of high-frequency conductive hearing loss has been limited due to gaps in previous research on the subject, and clinicians often assume that an audiogram showing high-frequency conductive hearing loss is flawed. This study aims to improve the diagnostic utility of high-frequency conductive hearing loss in cases of partial ossicular discontinuity by (1) making use of a control population against which to compare the audiometry of partial ossicular discontinuity patients and (2) examining the correlation between high-frequency conductive hearing loss and partial ossicular discontinuity under controlled experimental conditions on fresh cadaveric temporal bones. Furthermore, ear-canal measurements of umbo velocity and wideband acoustic immittance measurements were investigated to determine the usefulness regarding diagnosis of ossicular discontinuity. Design: The authors analyzed audiograms from 66 patients with either form of surgically confirmed ossicular discontinuity and no confounding pathologies. The authors also analyzed umbo velocity (n = 29) and power reflectance (n = 12) measurements from a subset of these patients. Finally, the authors performed experiments on six fresh temporal bone specimens to study the differing mechanical effects of complete and partial discontinuity. The mechanical effects of these lesions were assessed via laser Doppler measurements of stapes velocity. In a subset of the specimen (n = 4), wideband acoustic immittance measurements were also collected. Results: (1) Calculations comparing the air-bone gap (ABG) at high and low frequencies show that when high-frequency ABGs are larger than low-frequency ABGs, the surgeon usually reported soft-tissue bands at the point of discontinuity. However, in cases with larger low-frequency ABGs and flat ABGs across frequencies, some partial discontinuities as well as complete discontinuities were reported. (2) Analysis of umbo velocity and power reflectance (calculated from wideband acoustic immittance) in patients reveal no significant difference across frequencies between the two types of ossicular discontinuities. (3) Temporal bone experiments reveal that partial discontinuity results in a greater loss in stapes velocity at high frequencies when compared with low frequencies, whereas with complete discontinuity, large losses in stapes velocity occur at all frequencies. Conclusion: The clinical and experimental findings suggest that when encountering larger ABGs at high frequencies when compared with low frequencies, partial ossicular discontinuity should be considered in the differential diagnosis.

Original languageEnglish (US)
Pages (from-to)206-215
Number of pages10
JournalEar and hearing
Volume37
Issue number2
DOIs
StatePublished - Mar 1 2016

Fingerprint

Conductive Hearing Loss
High-Frequency Hearing Loss
Stapes
Temporal Bone
Acoustics
Ear Canal
Bone and Bones
Audiometry
Tympanic Membrane
Lasers
Differential Diagnosis
Joints
Air
Pathology
Research
Population

Keywords

  • Air-bone gap
  • Audiogram
  • Laser Doppler vibrometry
  • Ossicular discontinuity
  • Ossicular disruption
  • Ossicular interruption
  • Wideband immittance

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Speech and Hearing

Cite this

Farahmand, R. B., Merchant, G. R., Lookabaugh, S. A., Röösli, C., Ulku, C. H., McKenna, M. J., ... Nakajima, H. H. (2016). The Audiometric and Mechanical Effects of Partial Ossicular Discontinuity. Ear and hearing, 37(2), 206-215. https://doi.org/10.1097/AUD.0000000000000239

The Audiometric and Mechanical Effects of Partial Ossicular Discontinuity. / Farahmand, Rosemary B.; Merchant, Gabrielle R.; Lookabaugh, Sarah A.; Röösli, Christof; Ulku, Cagatay H.; McKenna, Michael J.; De Venecia, Ronald K.; Halpin, Christopher F.; Rosowski, John J.; Nakajima, Hideko H.

In: Ear and hearing, Vol. 37, No. 2, 01.03.2016, p. 206-215.

Research output: Contribution to journalArticle

Farahmand, RB, Merchant, GR, Lookabaugh, SA, Röösli, C, Ulku, CH, McKenna, MJ, De Venecia, RK, Halpin, CF, Rosowski, JJ & Nakajima, HH 2016, 'The Audiometric and Mechanical Effects of Partial Ossicular Discontinuity', Ear and hearing, vol. 37, no. 2, pp. 206-215. https://doi.org/10.1097/AUD.0000000000000239
Farahmand RB, Merchant GR, Lookabaugh SA, Röösli C, Ulku CH, McKenna MJ et al. The Audiometric and Mechanical Effects of Partial Ossicular Discontinuity. Ear and hearing. 2016 Mar 1;37(2):206-215. https://doi.org/10.1097/AUD.0000000000000239
Farahmand, Rosemary B. ; Merchant, Gabrielle R. ; Lookabaugh, Sarah A. ; Röösli, Christof ; Ulku, Cagatay H. ; McKenna, Michael J. ; De Venecia, Ronald K. ; Halpin, Christopher F. ; Rosowski, John J. ; Nakajima, Hideko H. / The Audiometric and Mechanical Effects of Partial Ossicular Discontinuity. In: Ear and hearing. 2016 ; Vol. 37, No. 2. pp. 206-215.
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AU - Merchant, Gabrielle R.

AU - Lookabaugh, Sarah A.

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AU - Ulku, Cagatay H.

AU - McKenna, Michael J.

AU - De Venecia, Ronald K.

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KW - Air-bone gap

KW - Audiogram

KW - Laser Doppler vibrometry

KW - Ossicular discontinuity

KW - Ossicular disruption

KW - Ossicular interruption

KW - Wideband immittance

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