The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes

Raul Alvarez-Venegas, Monther Sadder, Andrej Hlavacka, František Baluška, Yuannan Xia, Guoqing Lu, Alexey Firsov, Gautam Sarath, Hideaki Moriyama, Joseph G. Dubrovsky, Zoya V Avramova

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

The Arabidopsis homolog of trithorax, ATX1, regulates numerous functions in Arabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity, suggesting a regulatory pathway connecting lipid-signaling with nuclear functions. We propose a model to illustrate how plants may respond to stimuli (external or internal) that elevate cellular PI5P levels by altering expression of ATX1-controlled genes.

Original languageEnglish (US)
Pages (from-to)6049-6054
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number15
DOIs
StatePublished - Apr 11 2006

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Arabidopsis
Lipids
Homeobox Genes
Genes
Genome
phosphatidylinositol 5-phosphate

Keywords

  • Epigenetic regulation
  • Lipid signaling

ASJC Scopus subject areas

  • General

Cite this

The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes. / Alvarez-Venegas, Raul; Sadder, Monther; Hlavacka, Andrej; Baluška, František; Xia, Yuannan; Lu, Guoqing; Firsov, Alexey; Sarath, Gautam; Moriyama, Hideaki; Dubrovsky, Joseph G.; Avramova, Zoya V.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, No. 15, 11.04.2006, p. 6049-6054.

Research output: Contribution to journalArticle

Alvarez-Venegas, Raul ; Sadder, Monther ; Hlavacka, Andrej ; Baluška, František ; Xia, Yuannan ; Lu, Guoqing ; Firsov, Alexey ; Sarath, Gautam ; Moriyama, Hideaki ; Dubrovsky, Joseph G. ; Avramova, Zoya V. / The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes. In: Proceedings of the National Academy of Sciences of the United States of America. 2006 ; Vol. 103, No. 15. pp. 6049-6054.
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