The application of FAST-NMR for the identification of novel drug discovery targets

Robert Powers, Kelly A. Mercier, Jennifer C. Copeland

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

The continued success of genome sequencing projects has resulted in a wealth of information, but 40-50% of identified genes correspond to hypothetical proteins or proteins of unknown function. The functional annotation screening technology by NMR (FAST-NMR) screen was developed to assign a biological function for these unannotated proteins with a structure solved by the protein structure initiative. FAST-NMR is based on the premise that a biological function can be described by a similarity in binding sites and ligand interactions with proteins of known function. The resulting co-structure and functional assignment may provide a starting point for a drug discovery effort.

Original languageEnglish (US)
Pages (from-to)172-179
Number of pages8
JournalDrug Discovery Today
Volume13
Issue number3-4
DOIs
StatePublished - Feb 1 2008

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Drug Discovery
Technology
Proteins
Binding Sites
Genome
Ligands
Genes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

The application of FAST-NMR for the identification of novel drug discovery targets. / Powers, Robert; Mercier, Kelly A.; Copeland, Jennifer C.

In: Drug Discovery Today, Vol. 13, No. 3-4, 01.02.2008, p. 172-179.

Research output: Contribution to journalReview article

Powers, Robert ; Mercier, Kelly A. ; Copeland, Jennifer C. / The application of FAST-NMR for the identification of novel drug discovery targets. In: Drug Discovery Today. 2008 ; Vol. 13, No. 3-4. pp. 172-179.
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