The addition of manganese porphyrins during radiation inhibits prostate cancer growth and simultaneously protects normal prostate tissue from radiation damage

Arpita Chatterjee, Yuxiang Zhu, Qiang Tong, Elizabeth A. Kosmacek, Eliezer Z. Lichter, Rebecca E. Oberley-Deegan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Radiation therapy is commonly used for prostate cancer treatment; however, normal tissues can be damaged from the reactive oxygen species (ROS) produced by radiation. In separate reports, we and others have shown that manganese porphyrins (MnPs), ROS scavengers, protect normal cells from radiation-induced damage but inhibit prostate cancer cell growth. However, there have been no studies demonstrating that MnPs protect normal tissues, while inhibiting tumor growth in the same model. LNCaP or PC3 cells were orthotopically implanted into athymic mice and treated with radiation (2 Gy, for 5 consecutive days) in the presence or absence of MnPs. With radiation, MnPs enhanced overall life expectancy and significantly decreased the average tumor volume, as compared to the radiated alone group. MnPs enhanced lipid oxidation in tumor cells but reduced oxidative damage to normal prostate tissue adjacent to the prostate tumor in combination with radiation. Mechanistically, MnPs behave as pro-oxidants or antioxidants depending on the level of oxidative stress inside the treated cell. We found that MnPs act as pro-oxidants in prostate cancer cells, while in normal cells and tissues the MnPs act as antioxidants. For the first time, in the same in vivo model, this study reveals that MnPs enhance the tumoricidal effect of radiation and reduce oxidative damage to normal prostate tissue adjacent to the prostate tumor in the presence of radiation. This study suggests that MnPs are effective radio-protectors for radiation-mediated prostate cancer treatment.

Original languageEnglish (US)
Article number21
JournalAntioxidants
Volume7
Issue number1
DOIs
StatePublished - Jan 2018

Fingerprint

Radiation damage
Porphyrins
Manganese
Prostate
Prostatic Neoplasms
Radiation
Tissue
Growth
Tumors
Reactive Oxygen Species
Oncology
Cells
Neoplasms
Antioxidants
Radiation Dosage
Oxidative stress
Radiation Effects
Radiotherapy
Cell growth
Life Expectancy

Keywords

  • Lipid oxidation
  • Manganese porphyrin
  • Prostate cancer
  • ROS
  • Radiation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

The addition of manganese porphyrins during radiation inhibits prostate cancer growth and simultaneously protects normal prostate tissue from radiation damage. / Chatterjee, Arpita; Zhu, Yuxiang; Tong, Qiang; Kosmacek, Elizabeth A.; Lichter, Eliezer Z.; Oberley-Deegan, Rebecca E.

In: Antioxidants, Vol. 7, No. 1, 21, 01.2018.

Research output: Contribution to journalArticle

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