The activity of dispiro peroxides against Fasciola hepatica

Xiaofang Wang, Qingjie Zhao, Mireille Vargas, Yuxiang Dong, Kamaraj Sriraghavan, Jennifer Keiser, Jonathan L Vennerstrom

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50 mg/kg and two were partially curative at single doses of 25 mg/kg.

Original languageEnglish (US)
Pages (from-to)5320-5323
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number18
DOIs
StatePublished - Sep 15 2011

Fingerprint

Fasciola hepatica
Peroxides
Tetraoxanes
1,2,4-trioxane

Keywords

  • Artemisinin
  • Fasciola hepatica
  • Peroxide

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

The activity of dispiro peroxides against Fasciola hepatica. / Wang, Xiaofang; Zhao, Qingjie; Vargas, Mireille; Dong, Yuxiang; Sriraghavan, Kamaraj; Keiser, Jennifer; Vennerstrom, Jonathan L.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 21, No. 18, 15.09.2011, p. 5320-5323.

Research output: Contribution to journalArticle

Wang, Xiaofang ; Zhao, Qingjie ; Vargas, Mireille ; Dong, Yuxiang ; Sriraghavan, Kamaraj ; Keiser, Jennifer ; Vennerstrom, Jonathan L. / The activity of dispiro peroxides against Fasciola hepatica. In: Bioorganic and Medicinal Chemistry Letters. 2011 ; Vol. 21, No. 18. pp. 5320-5323.
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