Telomerase

Diagnostics, cancer therapeutics and tissue engineering

Michel M Ouellette, Kwangmoon Lee

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The enzyme telomerase has a key role in controlling the lifespan of human cells. It is absent from most somatic tissues but is reactivated in more than 85% of cancers, making the enzyme ideal as a marker of cancer cells and as a therapeutic target. In the context of normal human cells, the enzyme can extend cellular lifespan without causing cancer-associated changes or altering phenotypic properties. This capability could solve a major obstacle in the use of normal human cells for tissue engineering, that is, the induction of cellular senescence.

Original languageEnglish (US)
Pages (from-to)1231-1237
Number of pages7
JournalDrug Discovery Today
Volume6
Issue number23
DOIs
StatePublished - Dec 1 2001

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Telomerase
Tissue Engineering
Enzymes
Cell Engineering
Neoplasms
Human Engineering
Cell Aging
Therapeutics

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Telomerase : Diagnostics, cancer therapeutics and tissue engineering. / Ouellette, Michel M; Lee, Kwangmoon.

In: Drug Discovery Today, Vol. 6, No. 23, 01.12.2001, p. 1231-1237.

Research output: Contribution to journalReview article

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