tDCS Modulates Visual Gamma Oscillations and Basal Alpha Activity in Occipital Cortices

Evidence from MEG

Tony W Wilson, Timothy J. McDermott, Mackenzie S. Mills, Nathan M. Coolidge, Elizabeth C Heinrichs-Graham

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Transcranial direct-current stimulation (tDCS) is now a widely used method for modulating the human brain, but the resulting physiological effects are not understood. Recent studies have combined magnetoencephalography (MEG) with simultaneous tDCS to evaluate online changes in occipital alpha and gamma oscillations, but no study to date has quantified the offline (i.e., after tDCS) alterations in these responses. Thirty-five healthy adults received active or sham anodal tDCS to the occipital cortices, and then completed a visual stimulation paradigm during MEG that is known to elicit robust gamma and alpha oscillations. The resulting MEG data were imaged and peak voxel time series were extracted to evaluate tDCS effects. We found that tDCS to the occipital increased the amplitude of local gamma oscillations, and basal alpha levels during the baseline. tDCS was also associated with network-level effects, including increased gamma oscillations in the prefrontal cortex, parietal, and other visual attention regions. Finally, although tDCS did not modulate peak gamma frequency, this variable was inversely correlated with gamma amplitude, which is consistent with a GABA-gamma link. In conclusion, tDCS alters gamma oscillations and basal alpha levels. The net offline effects on gamma activity are consistent with the view that anodal tDCS decreases local GABA.

Original languageEnglish (US)
Pages (from-to)1597-1609
Number of pages13
JournalCerebral cortex (New York, N.Y. : 1991)
Volume28
Issue number5
DOIs
StatePublished - May 1 2018

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Magnetoencephalography
Occipital Lobe
gamma-Aminobutyric Acid
Transcranial Direct Current Stimulation
Photic Stimulation
Prefrontal Cortex

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

tDCS Modulates Visual Gamma Oscillations and Basal Alpha Activity in Occipital Cortices : Evidence from MEG. / Wilson, Tony W; McDermott, Timothy J.; Mills, Mackenzie S.; Coolidge, Nathan M.; Heinrichs-Graham, Elizabeth C.

In: Cerebral cortex (New York, N.Y. : 1991), Vol. 28, No. 5, 01.05.2018, p. 1597-1609.

Research output: Contribution to journalArticle

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