tDCS modulates behavioral performance and the neural oscillatory dynamics serving visual selective attention

Timothy J. McDermott, Alex I. Wiesman, Mackenzie S. Mills, Rachel K. Spooner, Nathan M. Coolidge, Amy L. Proskovec, Elizabeth C Heinrichs-Graham, Tony W Wilson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Transcranial direct-current stimulation (tDCS) is a noninvasive method for modulating human brain activity. Although there are several hypotheses about the net effects of tDCS on brain function, the field's understanding remains incomplete and this is especially true for neural oscillatory activity during cognitive task performance. In this study, we examined whether different polarities of occipital tDCS differentially alter flanker task performance and the underlying neural dynamics. To this end, 48 healthy adults underwent 20 min of anodal, cathodal, or sham occipital tDCS, and then completed a visual flanker task during high-density magnetoencephalography (MEG). The resulting oscillatory responses were imaged in the time-frequency domain using beamforming, and the effects of tDCS on task-related oscillations and spontaneous neural activity were assessed. The results indicated that anodal tDCS of the occipital cortices inhibited flanker task performance as measured by reaction time, elevated spontaneous activity in the theta (4–7 Hz) and alpha (9–14 Hz) bands in prefrontal and occipital cortices, respectively, and reduced task-related theta oscillatory activity in prefrontal cortices during task performance. Cathodal tDCS of the occipital cortices did not significantly affect behavior or any of these neuronal parameters in any brain region. Lastly, the power of theta oscillations in the prefrontal cortices was inversely correlated with reaction time. In conclusion, anodal tDCS modulated task-related oscillations and spontaneous activity across multiple cortical areas, both near the electrode and in distant sites that were putatively connected to the targeted regions.

Original languageEnglish (US)
Pages (from-to)729-740
Number of pages12
JournalHuman Brain Mapping
Volume40
Issue number3
DOIs
StatePublished - Feb 15 2019

Fingerprint

Task Performance and Analysis
Occipital Lobe
Prefrontal Cortex
Reaction Time
Brain
Magnetoencephalography
Transcranial Direct Current Stimulation
Human Activities
Electrodes

Keywords

  • alpha
  • direct-current stimulation
  • magnetoencephalography
  • oscillation
  • theta

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

McDermott, T. J., Wiesman, A. I., Mills, M. S., Spooner, R. K., Coolidge, N. M., Proskovec, A. L., ... Wilson, T. W. (2019). tDCS modulates behavioral performance and the neural oscillatory dynamics serving visual selective attention. Human Brain Mapping, 40(3), 729-740. https://doi.org/10.1002/hbm.24405

tDCS modulates behavioral performance and the neural oscillatory dynamics serving visual selective attention. / McDermott, Timothy J.; Wiesman, Alex I.; Mills, Mackenzie S.; Spooner, Rachel K.; Coolidge, Nathan M.; Proskovec, Amy L.; Heinrichs-Graham, Elizabeth C; Wilson, Tony W.

In: Human Brain Mapping, Vol. 40, No. 3, 15.02.2019, p. 729-740.

Research output: Contribution to journalArticle

McDermott TJ, Wiesman AI, Mills MS, Spooner RK, Coolidge NM, Proskovec AL et al. tDCS modulates behavioral performance and the neural oscillatory dynamics serving visual selective attention. Human Brain Mapping. 2019 Feb 15;40(3):729-740. https://doi.org/10.1002/hbm.24405
McDermott, Timothy J. ; Wiesman, Alex I. ; Mills, Mackenzie S. ; Spooner, Rachel K. ; Coolidge, Nathan M. ; Proskovec, Amy L. ; Heinrichs-Graham, Elizabeth C ; Wilson, Tony W. / tDCS modulates behavioral performance and the neural oscillatory dynamics serving visual selective attention. In: Human Brain Mapping. 2019 ; Vol. 40, No. 3. pp. 729-740.
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