Targeting matrix remodeling in cardiac hypertrophy and heart failure

Merry L. Lindsey, Francis G. Spinale

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Chronic pressure overload, such as that with hypertension, induces left ventricular (LV) remodeling characterized by increased mass, that is, LV hypertrophy (LVH). LVH can cause impaired diastolic function and thereby contribute to heart failure. The myocardial extracellular matrix undergoes significant remodeling in LVH contributing to abnormalities in diastolic function. Current pharmacological strategies for the treatment of hypertension only indirectly and/or incompletely affect the structure and composition of the myocardial matrix. Identifying crucial pathways involved in matrix remodeling in hypertension-induced LVH will aid in the selection of more relevant targets.

Original languageEnglish (US)
Pages (from-to)253-258
Number of pages6
JournalDrug Discovery Today: Therapeutic Strategies
Volume2
Issue number3
DOIs
StatePublished - Jan 1 2005

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ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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