Abstract
Aberrant metabolism mechanisms are a well-established hallmark of cancer. Exploiting tumor metabolism as a therapeutic target is being actively pursued. De novo synthesis of fatty acids by fatty acid synthase (FASN) is a particularly attractive mechanism to target because increased lipid synthesis is associated with more aggressive tumor. In particular, our work focuses on the reformulation of orlistat, an FDA-approved lipase inhibitor that also inhibits the thioesterase domain of FASN. We report on the rationale, synthesis, efficacy, delivery, and limitations of a novel nanoparticle formulation of orlistat in the goal of targeting the FASN pathway.
| Original language | English (US) |
|---|---|
| Title of host publication | Visualizing and Quantifying Drug Distribution in Tissue III |
| Editors | Kin Foong Chan, Conor L. Evans |
| Publisher | SPIE |
| ISBN (Electronic) | 9781510623606 |
| DOIs | |
| State | Published - Jan 1 2019 |
| Event | Visualizing and Quantifying Drug Distribution in Tissue III 2019 - San Francisco, United States Duration: Feb 2 2019 → … |
Publication series
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Volume | 10859 |
| ISSN (Print) | 1605-7422 |
Conference
| Conference | Visualizing and Quantifying Drug Distribution in Tissue III 2019 |
|---|---|
| Country | United States |
| City | San Francisco |
| Period | 2/2/19 → … |
Fingerprint
Keywords
- Chemoresistance
- Drug delivery
- Fatty acid synthase (FASN)
- Hyaluronic acid
- Lipogenesis
- Nanoparticle
- Synergy
- Tumor metabolism
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Biomaterials
- Radiology Nuclear Medicine and imaging
Cite this
Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistance. / Souchek, Joshua J.; Muraskin, Lindsey; Houser, Lucas; Vu, Quyen; Mohs, Aaron M.
Visualizing and Quantifying Drug Distribution in Tissue III. ed. / Kin Foong Chan; Conor L. Evans. SPIE, 2019. 1085909 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10859).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Targeting fatty acid synthase to inhibit tumor growth and overcome taxane resistance
AU - Souchek, Joshua J.
AU - Muraskin, Lindsey
AU - Houser, Lucas
AU - Vu, Quyen
AU - Mohs, Aaron M
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Aberrant metabolism mechanisms are a well-established hallmark of cancer. Exploiting tumor metabolism as a therapeutic target is being actively pursued. De novo synthesis of fatty acids by fatty acid synthase (FASN) is a particularly attractive mechanism to target because increased lipid synthesis is associated with more aggressive tumor. In particular, our work focuses on the reformulation of orlistat, an FDA-approved lipase inhibitor that also inhibits the thioesterase domain of FASN. We report on the rationale, synthesis, efficacy, delivery, and limitations of a novel nanoparticle formulation of orlistat in the goal of targeting the FASN pathway.
AB - Aberrant metabolism mechanisms are a well-established hallmark of cancer. Exploiting tumor metabolism as a therapeutic target is being actively pursued. De novo synthesis of fatty acids by fatty acid synthase (FASN) is a particularly attractive mechanism to target because increased lipid synthesis is associated with more aggressive tumor. In particular, our work focuses on the reformulation of orlistat, an FDA-approved lipase inhibitor that also inhibits the thioesterase domain of FASN. We report on the rationale, synthesis, efficacy, delivery, and limitations of a novel nanoparticle formulation of orlistat in the goal of targeting the FASN pathway.
KW - Chemoresistance
KW - Drug delivery
KW - Fatty acid synthase (FASN)
KW - Hyaluronic acid
KW - Lipogenesis
KW - Nanoparticle
KW - Synergy
KW - Tumor metabolism
UR - http://www.scopus.com/inward/record.url?scp=85065763946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065763946&partnerID=8YFLogxK
U2 - 10.1117/12.2512244
DO - 10.1117/12.2512244
M3 - Conference contribution
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Visualizing and Quantifying Drug Distribution in Tissue III
A2 - Chan, Kin Foong
A2 - Evans, Conor L.
PB - SPIE
ER -