Targeting colon and kidney: Pathophysiological determinants of design strategy

Ajit S. Narang, Ram I. Mahato

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations

Abstract

Targeted drug delivery to an organ or tissue is intended to bring the drug to its primary site of action. Thus, it can help improve the efcacy of the drug or prevent its undesired toxicities in other tissues or organs. In addition, sometimes targeted strategies are intended to avoid drug exposure to a specic organ or tissue. This can help avoid specic drug-related toxicities, increase systemic exposure, and achieve higher concentration at the target site. Most targeted drug delivery systems involve the use of macromolecular or particulate carriers, with the aim of modifying the pharmacokinetics and cellular distribution of the drug. In addition to achieving higher drug concentrations and/or prolonged exposure within the target cells, strategies can be designed to target organelles or specic compartments within the target cells. The overall goal of all drug-targeting strategies is the improvement of the efcacy and/or safety prole of a drug substance.

Original languageEnglish (US)
Title of host publicationTargeted Delivery of Small and Macromolecular Drugs
PublisherCRC Press
Pages351-370
Number of pages20
ISBN (Electronic)9781420087734
ISBN (Print)9781420087727
DOIs
StatePublished - Jan 1 2010

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ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Narang, A. S., & Mahato, R. I. (2010). Targeting colon and kidney: Pathophysiological determinants of design strategy. In Targeted Delivery of Small and Macromolecular Drugs (pp. 351-370). CRC Press. https://doi.org/10.1201/9781420087734