Targeted Discovery and Combinatorial Biosynthesis of Polycyclic Tetramate Macrolactam Combamides A-E

Yan Liu, Haoxin Wang, Rentai Song, Jining Chen, Tianhong Li, Yaoyao Li, Liangcheng Du, Yuemao Shen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Polycyclic tetramate macrolactams (PoTeMs) are a growing class of natural products with distinct structure and diverse biological activities. By promoter engineering and heterologous expression of the cryptic cbm gene cluster, four new PoTeMs, combamides A-E (1-4), were identified. Additionally, two new derivatives, combamides E (5) and F (6), were generated via combinatorial biosynthesis. Together, our findings provide a sound base for expanding the structure diversities of PoTeMs through genome mining and combinatorial biosynthesis.

Original languageEnglish (US)
Pages (from-to)3504-3508
Number of pages5
JournalOrganic Letters
Volume20
Issue number12
DOIs
StatePublished - Jun 15 2018

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Cite this

Targeted Discovery and Combinatorial Biosynthesis of Polycyclic Tetramate Macrolactam Combamides A-E. / Liu, Yan; Wang, Haoxin; Song, Rentai; Chen, Jining; Li, Tianhong; Li, Yaoyao; Du, Liangcheng; Shen, Yuemao.

In: Organic Letters, Vol. 20, No. 12, 15.06.2018, p. 3504-3508.

Research output: Contribution to journalArticle

Liu, Yan ; Wang, Haoxin ; Song, Rentai ; Chen, Jining ; Li, Tianhong ; Li, Yaoyao ; Du, Liangcheng ; Shen, Yuemao. / Targeted Discovery and Combinatorial Biosynthesis of Polycyclic Tetramate Macrolactam Combamides A-E. In: Organic Letters. 2018 ; Vol. 20, No. 12. pp. 3504-3508.
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