Target cell defense prevents the development of diabetes after viral infection

Malin Flodström, Amy Maday, Deepika Balakrishna, Mary Malo Cleary, Akihiko Yoshimura, Nora Sarvetnick

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

The mechanisms that regulate susceptibility to virus-induced autoimmunity remain undefined. We establish here a fundamental link between the responsiveness of target pancreatic β cells to interferons (IFNs) and prevention of coxsackievirus B4 (CVB4)-induced diabetes. We found that an intact β cell response to IFNs was critical in preventing disease in infected hosts. The antiviral defense, raised by β cells in response to IFNs, resulted in a reduced permissiveness to infection and subsequent natural killer (NK) cell-dependent death. These results show that β cell defenses are critical for β cell survival during CVB4 infection and suggest an important role for IFNs in preserving NK cell tolerance to β cells during viral infection. Thus, alterations in target cell defenses can critically influence susceptibility to disease.

Original languageEnglish (US)
Pages (from-to)373-382
Number of pages10
JournalNature Immunology
Volume3
Issue number4
DOIs
StatePublished - Apr 2002

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Virus Diseases
Interferons
Natural Killer Cells
Permissiveness
Coxsackievirus Infections
Enterovirus
Disease Susceptibility
Autoimmunity
Antiviral Agents
Cell Survival
Cell Death
Viruses
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Flodström, M., Maday, A., Balakrishna, D., Cleary, M. M., Yoshimura, A., & Sarvetnick, N. (2002). Target cell defense prevents the development of diabetes after viral infection. Nature Immunology, 3(4), 373-382. https://doi.org/10.1038/ni771

Target cell defense prevents the development of diabetes after viral infection. / Flodström, Malin; Maday, Amy; Balakrishna, Deepika; Cleary, Mary Malo; Yoshimura, Akihiko; Sarvetnick, Nora.

In: Nature Immunology, Vol. 3, No. 4, 04.2002, p. 373-382.

Research output: Contribution to journalArticle

Flodström, M, Maday, A, Balakrishna, D, Cleary, MM, Yoshimura, A & Sarvetnick, N 2002, 'Target cell defense prevents the development of diabetes after viral infection', Nature Immunology, vol. 3, no. 4, pp. 373-382. https://doi.org/10.1038/ni771
Flodström, Malin ; Maday, Amy ; Balakrishna, Deepika ; Cleary, Mary Malo ; Yoshimura, Akihiko ; Sarvetnick, Nora. / Target cell defense prevents the development of diabetes after viral infection. In: Nature Immunology. 2002 ; Vol. 3, No. 4. pp. 373-382.
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