Tandem BRCT domains: DNA's praetorian guard

Rafael D. Mesquita, Nicholas T. Woods, Eloy S. Seabra-Junior, Alvaro N.A. Monteiro

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The cell's ability to sense and respond to specific stimuli is a complex system derived from precisely regulated protein-protein interactions. Some of these protein-protein interactions are mediated by the recognition of linear peptide motifs by protein modular domains. BRCT (BRCA1 C-terminal) domains and their linear motif counterparts, which contain phosphoserines, are one such pair-wise interaction system that seems to have evolved to serve as a surveillance system to monitor threats to the cell's genetic integrity. Evidence indicates that BRCT domains found in tandem can cooperate to provide sequence-specific binding of phosphorylated peptides as is the case for the breast and ovarian cancer susceptibility gene BRCA1 and the PAX transcription factor-interacting protein PAXIP1. Particular interest has been paid to tandem BRCT domains as "readers" of signaling events in the form of phosphorylated serine moieties induced by the activation of DNA damage response kinases ATM, ATR, and DNA-PK. However, given the diversity of tandem BRCT-containing proteins, questions remain as to the origin and evolution of this domain. Here, we discuss emerging views of the origin and evolving roles of tandem BRCT domain repeats in the DNA damage response.

Original languageEnglish (US)
Pages (from-to)1140-1146
Number of pages7
JournalGenes and Cancer
Volume1
Issue number11
DOIs
StatePublished - Jan 1 2010

Fingerprint

DNA
Proteins
DNA Damage
Phosphoserine
Peptides
Terminal Repeat Sequences
Neoplasm Genes
Ovarian Neoplasms
Serine
Transcription Factors
Phosphotransferases
Breast Neoplasms

Keywords

  • Brct
  • Cancer
  • Dna damage
  • Modular domains
  • Networks
  • Systems biology

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

Mesquita, R. D., Woods, N. T., Seabra-Junior, E. S., & Monteiro, A. N. A. (2010). Tandem BRCT domains: DNA's praetorian guard. Genes and Cancer, 1(11), 1140-1146. https://doi.org/10.1177/1947601910392988

Tandem BRCT domains : DNA's praetorian guard. / Mesquita, Rafael D.; Woods, Nicholas T.; Seabra-Junior, Eloy S.; Monteiro, Alvaro N.A.

In: Genes and Cancer, Vol. 1, No. 11, 01.01.2010, p. 1140-1146.

Research output: Contribution to journalArticle

Mesquita, RD, Woods, NT, Seabra-Junior, ES & Monteiro, ANA 2010, 'Tandem BRCT domains: DNA's praetorian guard', Genes and Cancer, vol. 1, no. 11, pp. 1140-1146. https://doi.org/10.1177/1947601910392988
Mesquita RD, Woods NT, Seabra-Junior ES, Monteiro ANA. Tandem BRCT domains: DNA's praetorian guard. Genes and Cancer. 2010 Jan 1;1(11):1140-1146. https://doi.org/10.1177/1947601910392988
Mesquita, Rafael D. ; Woods, Nicholas T. ; Seabra-Junior, Eloy S. ; Monteiro, Alvaro N.A. / Tandem BRCT domains : DNA's praetorian guard. In: Genes and Cancer. 2010 ; Vol. 1, No. 11. pp. 1140-1146.
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