Tandem application of C-C bond-forming reactions with reductive ozonolysis

Rachel Willand-Charnley, Patrick H. Dussault

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Several variants of reductive ozonolysis, defined here as the in situ generation of aldehydes or ketones during ozonolytic cleavage of alkenes, are demonstrated to work effectively in tandem with a number of C-C bond-forming reactions. For reactions involving basic nucleophiles (1,2- addition of Grignard reagents, Wittig or Horner-Emmons olefinations, and directed aldol reactions of lithium enolates), the one-pot process offers a rapid and high-yielding alternative to traditional two-step protocols.

Original languageEnglish (US)
Pages (from-to)42-47
Number of pages6
JournalJournal of Organic Chemistry
Volume78
Issue number1
DOIs
Publication statusPublished - Jan 4 2013

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ASJC Scopus subject areas

  • Organic Chemistry

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