52 Citations (Scopus)

Abstract

Despite active investigation of copolymer-1 (Cop-1) for nearly 40 years the mechanisms underlying its neuroprotective properties remain contentious. Nonetheless, current dogma for Cop-1 neuroprotective activities in autoimmune and neurodegenerative diseases include bystander suppression of autoimmune T cells and attenuation of microglial responses. In this report, we demonstrate that Cop-1 interacts directly with primary human neurons and decreases neuronal cell death induced by staurosporine or oxidative stress. This neuroprotection is mediated through protein kinase Ca and brain- derived neurotrophic factor. Dendritic cells (DQ uptake Cop-1, deliver it to the injury site, and release it in an active form. Interactions between Cop-1 and DC enhance DC blood brain barrier migration. In a rat model with optic nerve crush injury, Cop-1- primed DC induce T cell independent neuroprotection. These findings may facilitate the development of neuroprotective approaches using DC-mediated Cop-1 delivery to diseased nervous tissue.

Original languageEnglish (US)
Pages (from-to)3143-3154
Number of pages12
JournalEuropean Journal of Immunology
Volume37
Issue number11
DOIs
StatePublished - Nov 1 2007

Fingerprint

Optic Nerve Injuries
Nerve Crush
Bystander Effect
T-Lymphocytes
Nerve Tissue
Staurosporine
Brain-Derived Neurotrophic Factor
Blood-Brain Barrier
Neurodegenerative Diseases
Dendritic Cells
Protein Kinases
Autoimmune Diseases
Oxidative Stress
Cell Death
Neurons
Wounds and Injuries
Neuroprotection
Crush Injuries

Keywords

  • Dendritic cells
  • Inflammation
  • Neuroimmunology
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

T cell independent mechanism for copolymer-1-induced neuroprotection. / Liu, Jianuo; Johnson, Thomas V.; Lin, Jamie; Ramirez, Servio H.; Bronich, Tatiana K; Caplan, Steven H; Persidsky, Yuri; Gendelman, Howard Eliot; Kipnis, Jonathan.

In: European Journal of Immunology, Vol. 37, No. 11, 01.11.2007, p. 3143-3154.

Research output: Contribution to journalArticle

Liu, Jianuo ; Johnson, Thomas V. ; Lin, Jamie ; Ramirez, Servio H. ; Bronich, Tatiana K ; Caplan, Steven H ; Persidsky, Yuri ; Gendelman, Howard Eliot ; Kipnis, Jonathan. / T cell independent mechanism for copolymer-1-induced neuroprotection. In: European Journal of Immunology. 2007 ; Vol. 37, No. 11. pp. 3143-3154.
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AU - Persidsky, Yuri

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