Systemic side effects of transtympanic steroids

Ashley B. Robey, Trish Morrow, Gary Floyd Moore

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: Review largest series of patients treated with transtympanic steroids, including outcomes, steroid dosing and adverse outcomes. Review first reported cases of systemic side effects from transtympanic steroids. Methods: A retrospective case series of 166 patients who underwent placement of transtympanic Silverstein tube with microwick for steroid administration was reviewed. Results: 5/166 patients developed systemic side effects, 9/166 patients developed local side effects. 48/166 (29%) of patients had a persistent perforation after therapy. The percent of patients with improvement as a function of symptoms: hearing loss 42%, tinnitus 56%, vertigo 68%, aural fullness 25% and dysequilibrium 66%. Conclusions: While our study revealed a significant risk of persistent tympanic membrane perforation, the incidence of systemic and local side effects from transtympanic steroid administration is low.

Original languageEnglish (US)
Pages (from-to)S217
JournalLaryngoscope
Volume120
Issue numberSUPPL. 4
DOIs
StatePublished - Dec 1 2010

Fingerprint

Steroids
Tympanic Membrane Perforation
Meniere Disease
Tinnitus
Hearing Loss
Incidence
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Systemic side effects of transtympanic steroids. / Robey, Ashley B.; Morrow, Trish; Moore, Gary Floyd.

In: Laryngoscope, Vol. 120, No. SUPPL. 4, 01.12.2010, p. S217.

Research output: Contribution to journalArticle

Robey, Ashley B. ; Morrow, Trish ; Moore, Gary Floyd. / Systemic side effects of transtympanic steroids. In: Laryngoscope. 2010 ; Vol. 120, No. SUPPL. 4. pp. S217.
@article{39a01ed3cbae46c9b1ee75e88cafb56b,
title = "Systemic side effects of transtympanic steroids",
abstract = "Objective: Review largest series of patients treated with transtympanic steroids, including outcomes, steroid dosing and adverse outcomes. Review first reported cases of systemic side effects from transtympanic steroids. Methods: A retrospective case series of 166 patients who underwent placement of transtympanic Silverstein tube with microwick for steroid administration was reviewed. Results: 5/166 patients developed systemic side effects, 9/166 patients developed local side effects. 48/166 (29{\%}) of patients had a persistent perforation after therapy. The percent of patients with improvement as a function of symptoms: hearing loss 42{\%}, tinnitus 56{\%}, vertigo 68{\%}, aural fullness 25{\%} and dysequilibrium 66{\%}. Conclusions: While our study revealed a significant risk of persistent tympanic membrane perforation, the incidence of systemic and local side effects from transtympanic steroid administration is low.",
author = "Robey, {Ashley B.} and Trish Morrow and Moore, {Gary Floyd}",
year = "2010",
month = "12",
day = "1",
doi = "10.1002/lary.21684",
language = "English (US)",
volume = "120",
pages = "S217",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "SUPPL. 4",

}

TY - JOUR

T1 - Systemic side effects of transtympanic steroids

AU - Robey, Ashley B.

AU - Morrow, Trish

AU - Moore, Gary Floyd

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Objective: Review largest series of patients treated with transtympanic steroids, including outcomes, steroid dosing and adverse outcomes. Review first reported cases of systemic side effects from transtympanic steroids. Methods: A retrospective case series of 166 patients who underwent placement of transtympanic Silverstein tube with microwick for steroid administration was reviewed. Results: 5/166 patients developed systemic side effects, 9/166 patients developed local side effects. 48/166 (29%) of patients had a persistent perforation after therapy. The percent of patients with improvement as a function of symptoms: hearing loss 42%, tinnitus 56%, vertigo 68%, aural fullness 25% and dysequilibrium 66%. Conclusions: While our study revealed a significant risk of persistent tympanic membrane perforation, the incidence of systemic and local side effects from transtympanic steroid administration is low.

AB - Objective: Review largest series of patients treated with transtympanic steroids, including outcomes, steroid dosing and adverse outcomes. Review first reported cases of systemic side effects from transtympanic steroids. Methods: A retrospective case series of 166 patients who underwent placement of transtympanic Silverstein tube with microwick for steroid administration was reviewed. Results: 5/166 patients developed systemic side effects, 9/166 patients developed local side effects. 48/166 (29%) of patients had a persistent perforation after therapy. The percent of patients with improvement as a function of symptoms: hearing loss 42%, tinnitus 56%, vertigo 68%, aural fullness 25% and dysequilibrium 66%. Conclusions: While our study revealed a significant risk of persistent tympanic membrane perforation, the incidence of systemic and local side effects from transtympanic steroid administration is low.

UR - http://www.scopus.com/inward/record.url?scp=78651445356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78651445356&partnerID=8YFLogxK

U2 - 10.1002/lary.21684

DO - 10.1002/lary.21684

M3 - Article

C2 - 21225815

AN - SCOPUS:78651445356

VL - 120

SP - S217

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - SUPPL. 4

ER -