Systemic kappa light-chain deposition. An ultrastructural and immunohistochemical study

James Linder, B. P. Croker, R. T. Vollmer, J. Shelburne

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

This report describes the pathology of kappa light-chain deposition in a 55-year-old patient who presented with respiratory insufficiency and hepatomegaly. Biopsies of lung and liver showed PAS-positive deposits which did not stain with congo red, crystal violet, or thioflavin-T. By indirect immunoperoxidase techniques, the deposits were composed of kappa light-chain immunoglobulin. Electron microscopy revealed granular and fibrillar electron-dense material which lacked the characteristics of amyloid. Subsequent clinical studies showed this patient had a plasma cell dyscrasia. These data show that kappa light-chain deposition is not limited to the kidney, and that the first manifestation of a plasma cell dyscrasia may be systemic deposits of light chain. These deposits can be distinguished from amyloid by their immunochemical, tinctorial, and ultrastructural appearance.

Original languageEnglish (US)
Pages (from-to)85-93
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume7
Issue number1
StatePublished - Jan 1 1983

Fingerprint

Paraproteinemias
Light
Amyloid
Immunoglobulin kappa-Chains
Gentian Violet
Congo Red
Hepatomegaly
Immunoenzyme Techniques
Respiratory Insufficiency
Electron Microscopy
Coloring Agents
Electrons
Pathology
Staining and Labeling
Kidney
Biopsy
Lung
Liver
thioflavin T
Clinical Studies

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Systemic kappa light-chain deposition. An ultrastructural and immunohistochemical study. / Linder, James; Croker, B. P.; Vollmer, R. T.; Shelburne, J.

In: American Journal of Surgical Pathology, Vol. 7, No. 1, 01.01.1983, p. 85-93.

Research output: Contribution to journalArticle

Linder, James ; Croker, B. P. ; Vollmer, R. T. ; Shelburne, J. / Systemic kappa light-chain deposition. An ultrastructural and immunohistochemical study. In: American Journal of Surgical Pathology. 1983 ; Vol. 7, No. 1. pp. 85-93.
@article{28ff4762096d427596f5997af3271862,
title = "Systemic kappa light-chain deposition. An ultrastructural and immunohistochemical study",
abstract = "This report describes the pathology of kappa light-chain deposition in a 55-year-old patient who presented with respiratory insufficiency and hepatomegaly. Biopsies of lung and liver showed PAS-positive deposits which did not stain with congo red, crystal violet, or thioflavin-T. By indirect immunoperoxidase techniques, the deposits were composed of kappa light-chain immunoglobulin. Electron microscopy revealed granular and fibrillar electron-dense material which lacked the characteristics of amyloid. Subsequent clinical studies showed this patient had a plasma cell dyscrasia. These data show that kappa light-chain deposition is not limited to the kidney, and that the first manifestation of a plasma cell dyscrasia may be systemic deposits of light chain. These deposits can be distinguished from amyloid by their immunochemical, tinctorial, and ultrastructural appearance.",
author = "James Linder and Croker, {B. P.} and Vollmer, {R. T.} and J. Shelburne",
year = "1983",
month = "1",
day = "1",
language = "English (US)",
volume = "7",
pages = "85--93",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Systemic kappa light-chain deposition. An ultrastructural and immunohistochemical study

AU - Linder, James

AU - Croker, B. P.

AU - Vollmer, R. T.

AU - Shelburne, J.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - This report describes the pathology of kappa light-chain deposition in a 55-year-old patient who presented with respiratory insufficiency and hepatomegaly. Biopsies of lung and liver showed PAS-positive deposits which did not stain with congo red, crystal violet, or thioflavin-T. By indirect immunoperoxidase techniques, the deposits were composed of kappa light-chain immunoglobulin. Electron microscopy revealed granular and fibrillar electron-dense material which lacked the characteristics of amyloid. Subsequent clinical studies showed this patient had a plasma cell dyscrasia. These data show that kappa light-chain deposition is not limited to the kidney, and that the first manifestation of a plasma cell dyscrasia may be systemic deposits of light chain. These deposits can be distinguished from amyloid by their immunochemical, tinctorial, and ultrastructural appearance.

AB - This report describes the pathology of kappa light-chain deposition in a 55-year-old patient who presented with respiratory insufficiency and hepatomegaly. Biopsies of lung and liver showed PAS-positive deposits which did not stain with congo red, crystal violet, or thioflavin-T. By indirect immunoperoxidase techniques, the deposits were composed of kappa light-chain immunoglobulin. Electron microscopy revealed granular and fibrillar electron-dense material which lacked the characteristics of amyloid. Subsequent clinical studies showed this patient had a plasma cell dyscrasia. These data show that kappa light-chain deposition is not limited to the kidney, and that the first manifestation of a plasma cell dyscrasia may be systemic deposits of light chain. These deposits can be distinguished from amyloid by their immunochemical, tinctorial, and ultrastructural appearance.

UR - http://www.scopus.com/inward/record.url?scp=0020657149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020657149&partnerID=8YFLogxK

M3 - Article

VL - 7

SP - 85

EP - 93

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 1

ER -