Systematic review of basic oral care for the management of oral mucositis in cancer patients

Deborah B. McGuire, Janet S. Fulton, Jumin Park, Carlton G. Brown, M. Elvira P Correa, June G Eilers, Sharon Elad, Faith Gibson, Loree K. Oberle-Edwards, Joanne Bowen, Rajesh V. Lalla

Research output: Contribution to journalReview article

100 Citations (Scopus)

Abstract

Purpose: The purpose of this project was to evaluate research in basic oral care interventions to update evidence-based practice guidelines for preventing and treating oral mucositis (OM) in cancer patients undergoing radio- or chemotherapy. Methods: A systematic review of available literature was conducted by the Basic Oral Care Section of the Mucositis Study Group of MASCC/ISOO. Seven interventions - oral care protocols, dental care, normal saline, sodium bicarbonate, mixed medication mouthwash, chlorhexidine, and calcium phosphate - were evaluated using the Hadorn (J Clin Epidemiol 49:749-754, 1996) criteria to determine level of evidence, followed by a guideline determination of one of the following: recommendation, suggestion, or no guideline possible, using Somerfield's (Classic Pap Cur Comments 4:881-886, 2000) schema. Results: Fifty-two published papers were examined by treatment population (radiotherapy, chemotherapy, and hematopoietic stem cell transplant) and by whether the intervention aimed to prevent or treat OM. The resulting practice suggestions included using oral care protocols for preventing OM across all treatment modalities and age groups and not using chlorhexidine mouthwash for preventing OM in adults with head and neck cancer undergoing radiotherapy. Considering inadequate and/or conflicting evidence, no guidelines for prevention or treatment of OM were possible for the interventions of dental care, normal saline, sodium bicarbonate, mixed medication mouthwash, chlorhexidine in patients receiving chemotherapy or hematopoietic stem cell transplant, or calcium phosphate. Conclusions: The evidence for basic oral care interventions supports the use of oral care protocols in patient populations receiving radiation and/or chemotherapy and does not support chlorhexidine for prevention of mucositis in head and neck cancer patients receiving radiotherapy. Additional well-designed research is needed for other interventions to improve the amount and quality of evidence guiding future clinical care.

Original languageEnglish (US)
Pages (from-to)3165-3177
Number of pages13
JournalSupportive Care in Cancer
Volume21
Issue number11
DOIs
StatePublished - Nov 1 2013

Fingerprint

Stomatitis
Chlorhexidine
Mouthwashes
Radiotherapy
Drug Therapy
Mucositis
Sodium Bicarbonate
Dental Care
Guidelines
Neoplasms
Head and Neck Neoplasms
Hematopoietic Stem Cells
Transplants
Evidence-Based Practice
Practice Guidelines
Research
Population
Therapeutics
Age Groups
Radiation

Keywords

  • Basic oral care
  • Calcium phosphate
  • Chlorhexidine
  • Oral mucositis
  • Saline
  • Sodium bicarbonate

ASJC Scopus subject areas

  • Oncology

Cite this

McGuire, D. B., Fulton, J. S., Park, J., Brown, C. G., Correa, M. E. P., Eilers, J. G., ... Lalla, R. V. (2013). Systematic review of basic oral care for the management of oral mucositis in cancer patients. Supportive Care in Cancer, 21(11), 3165-3177. https://doi.org/10.1007/s00520-013-1942-0

Systematic review of basic oral care for the management of oral mucositis in cancer patients. / McGuire, Deborah B.; Fulton, Janet S.; Park, Jumin; Brown, Carlton G.; Correa, M. Elvira P; Eilers, June G; Elad, Sharon; Gibson, Faith; Oberle-Edwards, Loree K.; Bowen, Joanne; Lalla, Rajesh V.

In: Supportive Care in Cancer, Vol. 21, No. 11, 01.11.2013, p. 3165-3177.

Research output: Contribution to journalReview article

McGuire, DB, Fulton, JS, Park, J, Brown, CG, Correa, MEP, Eilers, JG, Elad, S, Gibson, F, Oberle-Edwards, LK, Bowen, J & Lalla, RV 2013, 'Systematic review of basic oral care for the management of oral mucositis in cancer patients', Supportive Care in Cancer, vol. 21, no. 11, pp. 3165-3177. https://doi.org/10.1007/s00520-013-1942-0
McGuire, Deborah B. ; Fulton, Janet S. ; Park, Jumin ; Brown, Carlton G. ; Correa, M. Elvira P ; Eilers, June G ; Elad, Sharon ; Gibson, Faith ; Oberle-Edwards, Loree K. ; Bowen, Joanne ; Lalla, Rajesh V. / Systematic review of basic oral care for the management of oral mucositis in cancer patients. In: Supportive Care in Cancer. 2013 ; Vol. 21, No. 11. pp. 3165-3177.
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abstract = "Purpose: The purpose of this project was to evaluate research in basic oral care interventions to update evidence-based practice guidelines for preventing and treating oral mucositis (OM) in cancer patients undergoing radio- or chemotherapy. Methods: A systematic review of available literature was conducted by the Basic Oral Care Section of the Mucositis Study Group of MASCC/ISOO. Seven interventions - oral care protocols, dental care, normal saline, sodium bicarbonate, mixed medication mouthwash, chlorhexidine, and calcium phosphate - were evaluated using the Hadorn (J Clin Epidemiol 49:749-754, 1996) criteria to determine level of evidence, followed by a guideline determination of one of the following: recommendation, suggestion, or no guideline possible, using Somerfield's (Classic Pap Cur Comments 4:881-886, 2000) schema. Results: Fifty-two published papers were examined by treatment population (radiotherapy, chemotherapy, and hematopoietic stem cell transplant) and by whether the intervention aimed to prevent or treat OM. The resulting practice suggestions included using oral care protocols for preventing OM across all treatment modalities and age groups and not using chlorhexidine mouthwash for preventing OM in adults with head and neck cancer undergoing radiotherapy. Considering inadequate and/or conflicting evidence, no guidelines for prevention or treatment of OM were possible for the interventions of dental care, normal saline, sodium bicarbonate, mixed medication mouthwash, chlorhexidine in patients receiving chemotherapy or hematopoietic stem cell transplant, or calcium phosphate. Conclusions: The evidence for basic oral care interventions supports the use of oral care protocols in patient populations receiving radiation and/or chemotherapy and does not support chlorhexidine for prevention of mucositis in head and neck cancer patients receiving radiotherapy. Additional well-designed research is needed for other interventions to improve the amount and quality of evidence guiding future clinical care.",
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N2 - Purpose: The purpose of this project was to evaluate research in basic oral care interventions to update evidence-based practice guidelines for preventing and treating oral mucositis (OM) in cancer patients undergoing radio- or chemotherapy. Methods: A systematic review of available literature was conducted by the Basic Oral Care Section of the Mucositis Study Group of MASCC/ISOO. Seven interventions - oral care protocols, dental care, normal saline, sodium bicarbonate, mixed medication mouthwash, chlorhexidine, and calcium phosphate - were evaluated using the Hadorn (J Clin Epidemiol 49:749-754, 1996) criteria to determine level of evidence, followed by a guideline determination of one of the following: recommendation, suggestion, or no guideline possible, using Somerfield's (Classic Pap Cur Comments 4:881-886, 2000) schema. Results: Fifty-two published papers were examined by treatment population (radiotherapy, chemotherapy, and hematopoietic stem cell transplant) and by whether the intervention aimed to prevent or treat OM. The resulting practice suggestions included using oral care protocols for preventing OM across all treatment modalities and age groups and not using chlorhexidine mouthwash for preventing OM in adults with head and neck cancer undergoing radiotherapy. Considering inadequate and/or conflicting evidence, no guidelines for prevention or treatment of OM were possible for the interventions of dental care, normal saline, sodium bicarbonate, mixed medication mouthwash, chlorhexidine in patients receiving chemotherapy or hematopoietic stem cell transplant, or calcium phosphate. Conclusions: The evidence for basic oral care interventions supports the use of oral care protocols in patient populations receiving radiation and/or chemotherapy and does not support chlorhexidine for prevention of mucositis in head and neck cancer patients receiving radiotherapy. Additional well-designed research is needed for other interventions to improve the amount and quality of evidence guiding future clinical care.

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