Abstract
An efficient synthesis of a versatile scaffold 3, anti-2-chloro-3-hydroxy ester can be achieved via a boron mediated diastereofacial anti-aldol reaction of 2-(N methylbenzyl-N 2,4,6-trimethylbenzyl)-amino-l-phenylpropanol chloroester 1 and the uridyl aldehyde derivative 2. Generation of uridine-amino alcohol-based library is demonstrated by using the scaffold 3.
Original language | English (US) |
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Pages (from-to) | 339-352 |
Number of pages | 14 |
Journal | Heterocycles |
Volume | 72 |
DOIs | |
State | Published - Apr 13 2007 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Pharmacology
- Organic Chemistry
Cite this
Synthetic studies toward the generation of uridine-amino alcohol-based small optimized libraries. / Kurosu, Michio; Narayanasamy, Prabagaran; Crick, Dean C.
In: Heterocycles, Vol. 72, 13.04.2007, p. 339-352.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthetic studies toward the generation of uridine-amino alcohol-based small optimized libraries
AU - Kurosu, Michio
AU - Narayanasamy, Prabagaran
AU - Crick, Dean C.
PY - 2007/4/13
Y1 - 2007/4/13
N2 - An efficient synthesis of a versatile scaffold 3, anti-2-chloro-3-hydroxy ester can be achieved via a boron mediated diastereofacial anti-aldol reaction of 2-(N methylbenzyl-N 2,4,6-trimethylbenzyl)-amino-l-phenylpropanol chloroester 1 and the uridyl aldehyde derivative 2. Generation of uridine-amino alcohol-based library is demonstrated by using the scaffold 3.
AB - An efficient synthesis of a versatile scaffold 3, anti-2-chloro-3-hydroxy ester can be achieved via a boron mediated diastereofacial anti-aldol reaction of 2-(N methylbenzyl-N 2,4,6-trimethylbenzyl)-amino-l-phenylpropanol chloroester 1 and the uridyl aldehyde derivative 2. Generation of uridine-amino alcohol-based library is demonstrated by using the scaffold 3.
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UR - http://www.scopus.com/inward/citedby.url?scp=34547898462&partnerID=8YFLogxK
U2 - 10.3987/COM-06-S(K)18
DO - 10.3987/COM-06-S(K)18
M3 - Article
AN - SCOPUS:34547898462
VL - 72
SP - 339
EP - 352
JO - Heterocycles
JF - Heterocycles
SN - 0385-5414
ER -