Synthetic studies toward the generation of uridine-amino alcohol-based small optimized libraries

Michio Kurosu; Prabagaran Narayanasamy; Dean C. Crick

doi:10.3987/COM-06-S(K)18

Synthetic studies toward the generation of uridine-amino alcohol-based small optimized libraries

Michio Kurosu, Prabagaran Narayanasamy, Dean C. Crick

Research output: Contribution to journal › Article

12 Scopus citations

Abstract

An efficient synthesis of a versatile scaffold 3, anti-2-chloro-3-hydroxy ester can be achieved via a boron mediated diastereofacial anti-aldol reaction of 2-(N methylbenzyl-N 2,4,6-trimethylbenzyl)-amino-l-phenylpropanol chloroester 1 and the uridyl aldehyde derivative 2. Generation of uridine-amino alcohol-based library is demonstrated by using the scaffold 3.

Original language	English (US)
Pages (from-to)	339-352
Number of pages	14
Journal	Heterocycles
Volume	72
DOIs	https://doi.org/10.3987/COM-06-S(K)18
State	Published - Apr 13 2007

Fingerprint

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

Cite this

Kurosu, M., Narayanasamy, P., & Crick, D. C. (2007). Synthetic studies toward the generation of uridine-amino alcohol-based small optimized libraries. Heterocycles, 72, 339-352. https://doi.org/10.3987/COM-06-S(K)18

@article{31c135dbbc4d46b892fa011d88a1a50f,

title = "Synthetic studies toward the generation of uridine-amino alcohol-based small optimized libraries",

abstract = "An efficient synthesis of a versatile scaffold 3, anti-2-chloro-3-hydroxy ester can be achieved via a boron mediated diastereofacial anti-aldol reaction of 2-(N methylbenzyl-N 2,4,6-trimethylbenzyl)-amino-l-phenylpropanol chloroester 1 and the uridyl aldehyde derivative 2. Generation of uridine-amino alcohol-based library is demonstrated by using the scaffold 3.",

author = "Michio Kurosu and Prabagaran Narayanasamy and Crick, {Dean C.}",

year = "2007",

month = apr

day = "13",

doi = "10.3987/COM-06-S(K)18",

language = "English (US)",

volume = "72",

pages = "339--352",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

}

TY - JOUR

T1 - Synthetic studies toward the generation of uridine-amino alcohol-based small optimized libraries

AU - Kurosu, Michio

AU - Narayanasamy, Prabagaran

AU - Crick, Dean C.

PY - 2007/4/13

Y1 - 2007/4/13

N2 - An efficient synthesis of a versatile scaffold 3, anti-2-chloro-3-hydroxy ester can be achieved via a boron mediated diastereofacial anti-aldol reaction of 2-(N methylbenzyl-N 2,4,6-trimethylbenzyl)-amino-l-phenylpropanol chloroester 1 and the uridyl aldehyde derivative 2. Generation of uridine-amino alcohol-based library is demonstrated by using the scaffold 3.

AB - An efficient synthesis of a versatile scaffold 3, anti-2-chloro-3-hydroxy ester can be achieved via a boron mediated diastereofacial anti-aldol reaction of 2-(N methylbenzyl-N 2,4,6-trimethylbenzyl)-amino-l-phenylpropanol chloroester 1 and the uridyl aldehyde derivative 2. Generation of uridine-amino alcohol-based library is demonstrated by using the scaffold 3.

UR - http://www.scopus.com/inward/record.url?scp=34547898462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547898462&partnerID=8YFLogxK

U2 - 10.3987/COM-06-S(K)18

DO - 10.3987/COM-06-S(K)18

M3 - Article

AN - SCOPUS:34547898462

VL - 72

SP - 339

EP - 352

JO - Heterocycles

JF - Heterocycles

SN - 0385-5414

ER -

Access to Document

10.3987/COM-06-S(K)18