Synthetic redesign of plant lipid metabolism

Richard P. Haslam, Olga Sayanova, Hae Jin Kim, Edgar B Cahoon, Johnathan A. Napier

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Plant seed lipid metabolism is an area of intensive research, including many examples of transgenic events in which oil composition has been modified. In the selected examples described in this review, progress towards the predictive manipulation of metabolism and the reconstitution of desired traits in a non-native host is considered. The advantages of a particular oilseed crop, Camelina sativa, as a flexible and utilitarian chassis for advanced metabolic engineering and applied synthetic biology are considered, as are the issues that still represent gaps in our ability to predictably alter plant lipid biosynthesis. Opportunities to deliver useful bio-based products via transgenic plants are described, some of which represent the most complex genetic engineering in plants to date. Future prospects are considered, with a focus on the desire to transition to more (computationally) directed manipulations of metabolism.

Original languageEnglish (US)
Pages (from-to)76-86
Number of pages11
JournalThe Plant journal : for cell and molecular biology
Volume87
Issue number1
DOIs
StatePublished - Jul 1 2016

Fingerprint

Lipid Metabolism
lipid metabolism
Camelina sativa
synthetic biology
biobased products
metabolic engineering
metabolism
oilseed crops
Spermatophytina
genetic engineering
Synthetic Biology
Metabolic Engineering
transgenic plants
Genetic Engineering
Genetically Modified Plants
genetically modified organisms
biosynthesis
oils
Seeds
Oils

Keywords

  • fatty acid metabolism
  • metabolic engineering
  • oil crops
  • plant biotechnology
  • predictive manipulation

ASJC Scopus subject areas

  • Genetics
  • Plant Science
  • Cell Biology

Cite this

Synthetic redesign of plant lipid metabolism. / Haslam, Richard P.; Sayanova, Olga; Kim, Hae Jin; Cahoon, Edgar B; Napier, Johnathan A.

In: The Plant journal : for cell and molecular biology, Vol. 87, No. 1, 01.07.2016, p. 76-86.

Research output: Contribution to journalReview article

Haslam, Richard P. ; Sayanova, Olga ; Kim, Hae Jin ; Cahoon, Edgar B ; Napier, Johnathan A. / Synthetic redesign of plant lipid metabolism. In: The Plant journal : for cell and molecular biology. 2016 ; Vol. 87, No. 1. pp. 76-86.
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