Synthesis of temperature-responsive heterobifunctional block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide)

Ye Zi You, David Oupický

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Heterobifunctional block copolymers of poly(ethylene glycol) (PEG) and poly(N-isopropylacrylamide) (PNIPAM) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization of NIPAM using a macromolecular trithiocarbonate PEG-based chain transfer agent. The polymerization showed all the expected features of living radical polymerization and allowed the synthesis of copolymers with different lengths of the PNIPAM block. The synthesized block copolymers contained a carboxylic acid group from L-lysine at the focal point and a trithiocarbonate group at the terminus of the PNIPAM block. The trithiocarbonate functionality was converted into a thiol group and used for conjugation of biotin to the end of the PNIPAM block. The copolymers exhibited temperature-dependent association behavior in aqueous solution with a phase transition of approximately 32°C. The described heterobifunctional block copolymers show promise for surface modifications with the potential for stimulus-controlled surface presentation of ligands attached to the terminus of the PNIPAM block.

Original languageEnglish (US)
Pages (from-to)98-105
Number of pages8
JournalBiomacromolecules
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2007

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Ethylene Glycol
Polyethylene glycols
Block copolymers
Temperature
Polymerization
Phase Transition
Copolymers
Biotin
Carboxylic Acids
Sulfhydryl Compounds
Lysine
Living polymerization
Free radical polymerization
poly-N-isopropylacrylamide
Carboxylic acids
Ligands
Surface treatment
Phase transitions
Association reactions
trithiocarbonic acid

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Synthesis of temperature-responsive heterobifunctional block copolymers of poly(ethylene glycol) and poly(N-isopropylacrylamide). / You, Ye Zi; Oupický, David.

In: Biomacromolecules, Vol. 8, No. 1, 01.01.2007, p. 98-105.

Research output: Contribution to journalArticle

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