Synthesis of spiro-bisperoxyketals

Prasanta Ghorai, Patrick H. Dussault, Chunhua Hu

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

(Chemical Equation Presented) Syntheses of spirocyclic bis-1,2-dioxolanes, bis-1,2-dioxanes, and bis-1,2-dioxepanes are achieved through intramolecular ketalizations of hydroperoxy ketones or intramolecular alkylations of gem-dihydroperoxides. The spiroperoxides have excellent thermal and chemical stability, and several display promising activity against P. falciparum.

Original languageEnglish (US)
Pages (from-to)2401-2404
Number of pages4
JournalOrganic Letters
Volume10
Issue number12
DOIs
StatePublished - Dec 1 2008

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Dioxanes
Dioxolanes
Gems
Chemical stability
alkylation
Alkylation
Ketones
ketones
Thermodynamic stability
thermal stability
Hot Temperature
Display devices
synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Synthesis of spiro-bisperoxyketals. / Ghorai, Prasanta; Dussault, Patrick H.; Hu, Chunhua.

In: Organic Letters, Vol. 10, No. 12, 01.12.2008, p. 2401-2404.

Research output: Contribution to journalArticle

Ghorai, Prasanta ; Dussault, Patrick H. ; Hu, Chunhua. / Synthesis of spiro-bisperoxyketals. In: Organic Letters. 2008 ; Vol. 10, No. 12. pp. 2401-2404.
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