Synthesis of bioreducible polycations with controlled topologies

Ye Zi You, Jun Jie Yan, Zhi Qiang Yu, David Oupicky

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bioreducible polycations, which possess disul fi de linkages in the backbone, have appeared as promising gene delivery carriers due to their high stability in extracellular physiological condition and bioreductiontriggered release of genetic materials, as well as reduced cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. Here, we describe the syntheses of bioreducible polycations, and the methods for control over their topology are also presented.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages121-132
Number of pages12
Volume948
DOIs
StatePublished - 2013
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume948
ISSN (Print)10643745

Fingerprint

Cytosol
Genes
Glutathione
polycations

Keywords

  • Bioreducible polycations
  • Controlled topologies
  • Michael-Addition polymerization
  • Poly(2-(dimethylamino)ethyl methacrylate)
  • Poly(amido amine)s
  • Polyethylenimine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Medicine(all)

Cite this

You, Y. Z., Yan, J. J., Yu, Z. Q., & Oupicky, D. (2013). Synthesis of bioreducible polycations with controlled topologies. In Methods in Molecular Biology (Vol. 948, pp. 121-132). (Methods in Molecular Biology; Vol. 948). https://doi.org/10.1007/978-1-62703-140-0-9

Synthesis of bioreducible polycations with controlled topologies. / You, Ye Zi; Yan, Jun Jie; Yu, Zhi Qiang; Oupicky, David.

Methods in Molecular Biology. Vol. 948 2013. p. 121-132 (Methods in Molecular Biology; Vol. 948).

Research output: Chapter in Book/Report/Conference proceedingChapter

You, YZ, Yan, JJ, Yu, ZQ & Oupicky, D 2013, Synthesis of bioreducible polycations with controlled topologies. in Methods in Molecular Biology. vol. 948, Methods in Molecular Biology, vol. 948, pp. 121-132. https://doi.org/10.1007/978-1-62703-140-0-9
You YZ, Yan JJ, Yu ZQ, Oupicky D. Synthesis of bioreducible polycations with controlled topologies. In Methods in Molecular Biology. Vol. 948. 2013. p. 121-132. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-62703-140-0-9
You, Ye Zi ; Yan, Jun Jie ; Yu, Zhi Qiang ; Oupicky, David. / Synthesis of bioreducible polycations with controlled topologies. Methods in Molecular Biology. Vol. 948 2013. pp. 121-132 (Methods in Molecular Biology).
@inbook{59ad8787884b45179600ca3e65b157ae,
title = "Synthesis of bioreducible polycations with controlled topologies",
abstract = "Bioreducible polycations, which possess disul fi de linkages in the backbone, have appeared as promising gene delivery carriers due to their high stability in extracellular physiological condition and bioreductiontriggered release of genetic materials, as well as reduced cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. Here, we describe the syntheses of bioreducible polycations, and the methods for control over their topology are also presented.",
keywords = "Bioreducible polycations, Controlled topologies, Michael-Addition polymerization, Poly(2-(dimethylamino)ethyl methacrylate), Poly(amido amine)s, Polyethylenimine",
author = "You, {Ye Zi} and Yan, {Jun Jie} and Yu, {Zhi Qiang} and David Oupicky",
year = "2013",
doi = "10.1007/978-1-62703-140-0-9",
language = "English (US)",
isbn = "9781627031394",
volume = "948",
series = "Methods in Molecular Biology",
pages = "121--132",
booktitle = "Methods in Molecular Biology",

}

TY - CHAP

T1 - Synthesis of bioreducible polycations with controlled topologies

AU - You, Ye Zi

AU - Yan, Jun Jie

AU - Yu, Zhi Qiang

AU - Oupicky, David

PY - 2013

Y1 - 2013

N2 - Bioreducible polycations, which possess disul fi de linkages in the backbone, have appeared as promising gene delivery carriers due to their high stability in extracellular physiological condition and bioreductiontriggered release of genetic materials, as well as reduced cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. Here, we describe the syntheses of bioreducible polycations, and the methods for control over their topology are also presented.

AB - Bioreducible polycations, which possess disul fi de linkages in the backbone, have appeared as promising gene delivery carriers due to their high stability in extracellular physiological condition and bioreductiontriggered release of genetic materials, as well as reduced cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. Here, we describe the syntheses of bioreducible polycations, and the methods for control over their topology are also presented.

KW - Bioreducible polycations

KW - Controlled topologies

KW - Michael-Addition polymerization

KW - Poly(2-(dimethylamino)ethyl methacrylate)

KW - Poly(amido amine)s

KW - Polyethylenimine

UR - http://www.scopus.com/inward/record.url?scp=84875012940&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875012940&partnerID=8YFLogxK

U2 - 10.1007/978-1-62703-140-0-9

DO - 10.1007/978-1-62703-140-0-9

M3 - Chapter

C2 - 23070767

SN - 9781627031394

VL - 948

T3 - Methods in Molecular Biology

SP - 121

EP - 132

BT - Methods in Molecular Biology

ER -