Synthesis of bioreducible polycations with controlled topologies

Ye Zi You, Jun Jie Yan, Zhi Qiang Yu, David Oupicky

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bioreducible polycations, which possess disul fi de linkages in the backbone, have appeared as promising gene delivery carriers due to their high stability in extracellular physiological condition and bioreductiontriggered release of genetic materials, as well as reduced cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. Here, we describe the syntheses of bioreducible polycations, and the methods for control over their topology are also presented.

Original languageEnglish (US)
Title of host publicationNanotechnology for Nucleic Acid Delivery
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages121-132
Number of pages12
ISBN (Print)9781627031394
DOIs
StatePublished - 2013

Publication series

NameMethods in Molecular Biology
Volume948
ISSN (Print)1064-3745

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Keywords

  • Bioreducible polycations
  • Controlled topologies
  • Michael-Addition polymerization
  • Poly(2-(dimethylamino)ethyl methacrylate)
  • Poly(amido amine)s
  • Polyethylenimine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

You, Y. Z., Yan, J. J., Yu, Z. Q., & Oupicky, D. (2013). Synthesis of bioreducible polycations with controlled topologies. In Nanotechnology for Nucleic Acid Delivery: Methods and Protocols (pp. 121-132). (Methods in Molecular Biology; Vol. 948). Humana Press Inc.. https://doi.org/10.1007/978-1-62703-140-0_9