Synthesis of aminopyrazole analogs and their evaluation as CDK inhibitors for cancer therapy

Sandeep Rana, Yogesh A. Sonawane, Margaret A. Taylor, Smitha Kizhake, Muhammad Zahid, Amarnath Natarajan

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We synthesized a library of aminopyrazole analogs to systematically explore the hydrophobic pocket adjacent to the hinge region and the solvent exposed region of cyclin dependent kinases. Structure-activity relationship studies identified an optimal substitution for the hydrophobic pocket and analog 24 as a potent and selective CDK2/5 inhibitor.

Original languageEnglish (US)
Pages (from-to)3736-3740
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume28
Issue number23-24
DOIs
StatePublished - Dec 15 2018

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Keywords

  • Aminopyrazole
  • Cyclin dependent kinase 2
  • Cyclin dependent kinase 5
  • Growth inhibition

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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