Synthesis of 2H-pyrroles by treatment of pyrrolidines with DDQ

Srinivasa R. Cheruku, Maniyan P. Padmanilayam, Jonathan L. Vennerstrom

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A mild and efficient synthesis of 2,2-dialkyl-3,5-diaryl-2H-pyrroles is described. Treatment of 2,2-dialkyl-3,5-diarylpyrrolidines with DDQ in dioxane for 12-24 h at rt afforded the corresponding 2H-pyrroles in 55-81% overall yields.

Original languageEnglish (US)
Pages (from-to)3701-3703
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number18
DOIs
StatePublished - Apr 28 2003

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Pyrrolidines
Pyrroles

Keywords

  • 2H-pyrroles
  • DDQ
  • Pyrroldines
  • Pyrrolines
  • Reductive cyclization
  • γ-nitroketones

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Synthesis of 2H-pyrroles by treatment of pyrrolidines with DDQ. / Cheruku, Srinivasa R.; Padmanilayam, Maniyan P.; Vennerstrom, Jonathan L.

In: Tetrahedron Letters, Vol. 44, No. 18, 28.04.2003, p. 3701-3703.

Research output: Contribution to journalArticle

Cheruku, Srinivasa R. ; Padmanilayam, Maniyan P. ; Vennerstrom, Jonathan L. / Synthesis of 2H-pyrroles by treatment of pyrrolidines with DDQ. In: Tetrahedron Letters. 2003 ; Vol. 44, No. 18. pp. 3701-3703.
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