Synthesis of (α,α-Difluoroalkyl)phosphonates by Displacement of Primary Triflates

David B Berkowitz, MariJean Eggen, Quanrong Shen, Darby G. Sloss

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Simple primary alkyl triflates and those derived from several monosaccharides are cleanly displaced by diethyl (lithiodifluoromethyl)phosphonate to provide the corresponding (α,α-difluoroalkyl)phosphonates in minutes at −78 °C.

Original languageEnglish (US)
Pages (from-to)6174-6176
Number of pages3
JournalJournal of Organic Chemistry
Volume58
Issue number23
DOIs
StatePublished - Jan 1 1993

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Organophosphonates
Monosaccharides

ASJC Scopus subject areas

  • Organic Chemistry

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Synthesis of (α,α-Difluoroalkyl)phosphonates by Displacement of Primary Triflates. / Berkowitz, David B; Eggen, MariJean; Shen, Quanrong; Sloss, Darby G.

In: Journal of Organic Chemistry, Vol. 58, No. 23, 01.01.1993, p. 6174-6176.

Research output: Contribution to journalArticle

Berkowitz, David B ; Eggen, MariJean ; Shen, Quanrong ; Sloss, Darby G. / Synthesis of (α,α-Difluoroalkyl)phosphonates by Displacement of Primary Triflates. In: Journal of Organic Chemistry. 1993 ; Vol. 58, No. 23. pp. 6174-6176.
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