Synthesis of (α,α-Difluoroalkyl)phosphonates by Displacement of Primary Triflates

David B Berkowitz, MariJean Eggen, Quanrong Shen, Darby G. Sloss

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Abstract

Simple primary alkyl triflates and those derived from several monosaccharides are cleanly displaced by diethyl (lithiodifluoromethyl)phosphonate to provide the corresponding (α,α-difluoroalkyl)phosphonates in minutes at −78 °C.

Original languageEnglish (US)
Pages (from-to)6174-6176
Number of pages3
JournalJournal of Organic Chemistry
Volume58
Issue number23
DOIs
Publication statusPublished - Jan 1 1993

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ASJC Scopus subject areas

  • Organic Chemistry

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