Synthesis, characterization, and antitumor activity of 5-iodouracil complexes

Udai P. Singh, Badri N. Singh, Animesh K. Ghose, Rakesh K Singh, Ajit Sodhi

Research output: Contribution to journalArticle

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Abstract

Complexes of 5-iodouracil (5IU) with Mn(II), Co(II), Cu(II), Zn(II), and Cd(II) ions have been prepared, characterized, and subjected to a screening system for evaluation of antitumor activity against Sarcoma-180 (S-180) and L 929 tumor cells. The complexes were characterized by their elemental analysis, infrared spectra, electronic spectra, magnetic measurements, and powder x-ray diffraction. The antitumor activity results indicate that some complexes have good antitumor activity both in vivo and in vitro against S-180 and L 929 tumor cells.

Original languageEnglish (US)
Pages (from-to)277-282
Number of pages6
JournalJournal of Inorganic Biochemistry
Volume44
Issue number4
DOIs
StatePublished - Jan 1 1991

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Tumors
Cells
Sarcoma 180
Magnetic variables measurement
Powders
Neoplasms
Spectrum Analysis
Screening
Diffraction
X-Rays
Ions
Infrared radiation
X rays
Chemical analysis
5-iodouracil
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Synthesis, characterization, and antitumor activity of 5-iodouracil complexes. / Singh, Udai P.; Singh, Badri N.; Ghose, Animesh K.; Singh, Rakesh K; Sodhi, Ajit.

In: Journal of Inorganic Biochemistry, Vol. 44, No. 4, 01.01.1991, p. 277-282.

Research output: Contribution to journalArticle

Singh, Udai P. ; Singh, Badri N. ; Ghose, Animesh K. ; Singh, Rakesh K ; Sodhi, Ajit. / Synthesis, characterization, and antitumor activity of 5-iodouracil complexes. In: Journal of Inorganic Biochemistry. 1991 ; Vol. 44, No. 4. pp. 277-282.
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