Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems

Dong Wang, Scott Miller, Monika Sima, Pavla Kopečková, Jindřich Kopeček

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Four polymeric bone-targeting conjugates were synthesized based on poly(ethylene glycol) (PEG, two conjugates) and poly [N-(2-hydroxypropyl)methacrylamide] (PHPMA, two conjugates). The well-known bone-targeting compounds, alendronate and aspartic acid peptide, were used as bone-targeting moieties. Fluorescein isothiocyanate (FITC) was attached to the conjugates as a model drug for detection purposes. The bone-targeting potential of these conjugates was tested in vitro with hydroxyapatite (HA) and in mice. The data obtained indicated that these novel delivery systems could specifically accumulate in the bone tissue.

Original languageEnglish (US)
Pages (from-to)853-859
Number of pages7
JournalBioconjugate Chemistry
Volume14
Issue number5
DOIs
StatePublished - Sep 1 2003

Fingerprint

Drug Delivery Systems
Bone
Bone and Bones
Water
Polyethylene glycols
Alendronate
Ethylene Glycol
Durapatite
Fluorescein
Hydroxyapatite
Aspartic Acid
Peptides
Targeted drug delivery
Tissue
Acids
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry

Cite this

Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems. / Wang, Dong; Miller, Scott; Sima, Monika; Kopečková, Pavla; Kopeček, Jindřich.

In: Bioconjugate Chemistry, Vol. 14, No. 5, 01.09.2003, p. 853-859.

Research output: Contribution to journalArticle

Wang, Dong ; Miller, Scott ; Sima, Monika ; Kopečková, Pavla ; Kopeček, Jindřich. / Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems. In: Bioconjugate Chemistry. 2003 ; Vol. 14, No. 5. pp. 853-859.
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