Synthesis and evaluation of a star amphiphilic block copolymer from poly(ε-caprolactone) and poly(ethylene glycol) as a potential drug delivery carrier

Fei Wang, Tatiana K Bronich, Alexander V. Kabanov, R. David Rauh, Jacques Roovers

Research output: Contribution to journalArticle

288 Citations (Scopus)

Abstract

A star polymer composed of amphiphilic block copolymer arms has been synthesized and characterized. The core of the star polymer is polyamidoamine (PAMAM) dendrimer, the inner block in the arm is lipophilic poly(ε- caprolactone) (PCL), and the outer block in the arm is hydrophilic poly(ethylene glycol) (PEG). The star-PCL polymer was synthesized first by ring-opening polymerization of ε-caprolactone with a PAMAM-OH dendrimer as initiator. The PEG polymer was then attached to the PCL terminus by an ester-forming reaction. Characterization with SEC, 1NMR, FTIR, TGA, and DSC confirmed the star structure of the polymers. The micelle formation of the star copolymer (star-PCL-PEG) was studied by fluorescence spectroscopy. Hydrophobic dyes and drugs can be encapsulated in the micelles. A loading capacity of up to 22% (w/w) was achieved with etoposide, a hydrophobic anticancer drug. A cytotoxicity assay demonstrated that the star-PCL-PEG copolymer is nontoxic in cell culture. This type of block copolymer can be used as a drug delivery carrier.

Original languageEnglish (US)
Pages (from-to)397-405
Number of pages9
JournalBioconjugate Chemistry
Volume16
Issue number2
DOIs
StatePublished - Mar 1 2005

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Drug Carriers
Ethylene Glycol
Drug delivery
Polyethylene glycols
Block copolymers
Stars
Polymers
Dendrimers
Micelles
Fluorescence Spectrometry
Copolymers
Etoposide
Fourier Transform Infrared Spectroscopy
Polymerization
Pharmaceutical Preparations
Esters
Coloring Agents
Ring opening polymerization
Fluorescence spectroscopy
Cell Culture Techniques

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Clinical Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Synthesis and evaluation of a star amphiphilic block copolymer from poly(ε-caprolactone) and poly(ethylene glycol) as a potential drug delivery carrier. / Wang, Fei; Bronich, Tatiana K; Kabanov, Alexander V.; Rauh, R. David; Roovers, Jacques.

In: Bioconjugate Chemistry, Vol. 16, No. 2, 01.03.2005, p. 397-405.

Research output: Contribution to journalArticle

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