Synthesis and characterization of valproic acid ester pro-drug micelles via an amphiphilic polycaprolactone block copolymer design

Suchithra A. Senevirathne, Suthida Boonsith, David Oupicky, Michael C. Biewer, Mihaela C. Stefan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The attachment of Histone deacetylase (HDAC) inhibitors via covalent bonds to biocompatible and biodegradable block copolymers provides a new research direction for cancer treatment. Herein, we report the synthesis and characterization of valproic acid ester pro-drug micelles of amphiphilic polycaprolactone block copolymers and their potential applications in drug delivery. This journal is

Original languageEnglish (US)
Pages (from-to)2386-2389
Number of pages4
JournalPolymer Chemistry
Volume6
Issue number13
DOIs
StatePublished - Apr 7 2015

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Polycaprolactone
Histone Deacetylase Inhibitors
Prodrugs
Valproic Acid
Micelles
Block copolymers
Esters
Covalent bonds
Oncology
Acids
Drug delivery
Research
Pharmaceutical Preparations
Neoplasms
polycaprolactone
Direction compound
Histone Deacetylases

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomedical Engineering
  • Polymers and Plastics
  • Organic Chemistry

Cite this

Synthesis and characterization of valproic acid ester pro-drug micelles via an amphiphilic polycaprolactone block copolymer design. / Senevirathne, Suchithra A.; Boonsith, Suthida; Oupicky, David; Biewer, Michael C.; Stefan, Mihaela C.

In: Polymer Chemistry, Vol. 6, No. 13, 07.04.2015, p. 2386-2389.

Research output: Contribution to journalArticle

Senevirathne, Suchithra A. ; Boonsith, Suthida ; Oupicky, David ; Biewer, Michael C. ; Stefan, Mihaela C. / Synthesis and characterization of valproic acid ester pro-drug micelles via an amphiphilic polycaprolactone block copolymer design. In: Polymer Chemistry. 2015 ; Vol. 6, No. 13. pp. 2386-2389.
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