Synthesis and characterization of valproic acid ester pro-drug micelles via an amphiphilic polycaprolactone block copolymer design

Suchithra A. Senevirathne, Suthida Boonsith, David Oupicky, Michael C. Biewer, Mihaela C. Stefan

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The attachment of Histone deacetylase (HDAC) inhibitors via covalent bonds to biocompatible and biodegradable block copolymers provides a new research direction for cancer treatment. Herein, we report the synthesis and characterization of valproic acid ester pro-drug micelles of amphiphilic polycaprolactone block copolymers and their potential applications in drug delivery. This journal is

Original languageEnglish (US)
Pages (from-to)2386-2389
Number of pages4
JournalPolymer Chemistry
Volume6
Issue number13
DOIs
StatePublished - Apr 7 2015

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ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

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