Synthesis and biological activity of chloromethyl ketones of leucine enkephalin

John T. Pelton, Robert B. Johnston, James L. Balk, Charles J. Schmidt, Edward B. Roche

Research output: Contribution to journalArticle

14 Scopus citations


The chloromethyl ketones of leucine enkephalin and D-Ala2-leucine enkephalin have been synthesized and tested for biological activity in the guinea pig ileum assay. The derivatives show an increased potency in morphine-like action in comparison to the corresponding enkephalins.

Original languageEnglish (US)
Pages (from-to)1391-1398
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number4
Publication statusPublished - Dec 31 1980



  • Bzl
  • CMK
  • TLC
  • benzyl
  • chloromethyl ketone
  • t-Boc
  • t-butyloxycarbonyl
  • thin layer chromatography

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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