Synaptic changes in the brain of subjects with schizophrenia

Gábor Faludi, Károly Mirnics

Research output: Contribution to journalArticle

81 Scopus citations

Abstract

Clinical, epidemiological, neuroimaging and postmortem data all suggest schizophrenia is a neurodevelopmental disorder, and that synaptic disturbances might play a critical role in developing the disease. In 1982, Feinberg proposed that the schizophrenia might arise as a result of abnormal synaptic pruning. His hypothesis has survived 40. years of accumulated data, and we review the critical findings related to synaptic dysfunction of schizophrenia. While it is clear that synaptic disturbances are integral and important for understanding the pathophysiology of schizophrenia, it has also become obvious that synaptic disturbances cannot be studied and understood as an independent disease hallmark, but only as a part of a complex network of homeostatic events. Development, glial-neural interaction, changes in energy homeostasis, diverse genetic predisposition, neuroimmune processes and environmental influences all can tip the delicate homeostatic balance of the synaptic morphology and connectivity in a uniquely individual fashion, thus contributing to the emergence of the various symptoms of this devastating disorder. Finally, we argue that based on a predominant change in gene expression pattern we can broadly sub-stratify schizophrenia into " synaptic" " oligodendroglial" , " metabolic" and " inflammatory" subclasses.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
JournalInternational Journal of Developmental Neuroscience
Volume29
Issue number3
DOIs
Publication statusPublished - May 1 2011

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Keywords

  • Gene expression
  • Postmortem
  • Pruning
  • Schizophrenia
  • Synapse

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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