Symptoms of periodontitis and antibody responses to Porphyromonas gingivalis in juvenile idiopathic arthritis

Lauren Lange, Geoffrey Milton Thiele, Courtney McCracken, Gabriel Wang, Lori A. Ponder, Sheila T. Angeles-Han, Kelly A. Rouster-Stevens, Aimee O. Hersh, Larry B. Vogler, John F. Bohnsack, Shelly Abramowicz, Ted R Mikuls, Sampath Prahalad

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: The association between rheumatoid arthritis (RA) and periodontitis is well established. Some children with juvenile idiopathic arthritis (JIA) phenotypically resemble adults with RA, characterized by the presence of anti-cyclic citrullinated peptide (CCP) antibodies. We sought to investigate an association between CCP-positive JIA and symptoms of periodontitis and antibodies to oral microbiota. Methods: Antibodies to oral pathogens Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum were measured using ELISA in 71 children with CCP-positive JIA and 74 children with CCP-negative JIA. Oral health history was collected from 37 children with CCP-positive JIA and 121 children with CCP-negative JIA. T-tests, Chi-square tests, Mann-Whitney U tests, and multivariable regression were used to compare the groups. Results: Compared to those with CCP-negative JIA, children with CCP-positive JIA were more likely to be female, older and non-Caucasian. Anti-P. gingivalis (p <0.003) and anti-P. intermedia (p <0.008) IgG antibody titers were higher in the CCP-positive cohort. Differences in P. gingivalis antibody titers remained significant after adjusting for age (p = 0.007). Children with CCP-positive JIA more likely reported tender/bleeding gums (43% vs. 24%, p < 0.02) compared to children with CCP-negative JIA. After controlling for age at collection, the odds of having tender/bleeding gums were 2.2 times higher in the CCP-positive group compared (95% CI 0.98 - 4.83; p = 0.056). Conclusions: Children with CCP-positive JIA have higher antibody titers to P. gingivalis and more symptoms of poor oral health, supporting a possible role for periodontitis in the etiology of CCP-positive JIA.

Original languageEnglish (US)
Article number8
JournalPediatric Rheumatology
Volume14
Issue number1
DOIs
StatePublished - Feb 9 2016

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Porphyromonas gingivalis
Juvenile Arthritis
Periodontitis
Antibody Formation
Antibodies
Prevotella intermedia
Oral Health
Gingiva
cyclic citrullinated peptide
Rheumatoid Arthritis
Fusobacterium nucleatum
Hemorrhage
Microbiota
Chi-Square Distribution
Nonparametric Statistics

Keywords

  • Anti-citrullinated peptide antibody
  • Juvenile idiopathic arthritis
  • Periodontitis
  • Porphyromonas gingivalis
  • Prevotella intermedia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Rheumatology
  • Immunology and Allergy

Cite this

Symptoms of periodontitis and antibody responses to Porphyromonas gingivalis in juvenile idiopathic arthritis. / Lange, Lauren; Thiele, Geoffrey Milton; McCracken, Courtney; Wang, Gabriel; Ponder, Lori A.; Angeles-Han, Sheila T.; Rouster-Stevens, Kelly A.; Hersh, Aimee O.; Vogler, Larry B.; Bohnsack, John F.; Abramowicz, Shelly; Mikuls, Ted R; Prahalad, Sampath.

In: Pediatric Rheumatology, Vol. 14, No. 1, 8, 09.02.2016.

Research output: Contribution to journalArticle

Lange, L, Thiele, GM, McCracken, C, Wang, G, Ponder, LA, Angeles-Han, ST, Rouster-Stevens, KA, Hersh, AO, Vogler, LB, Bohnsack, JF, Abramowicz, S, Mikuls, TR & Prahalad, S 2016, 'Symptoms of periodontitis and antibody responses to Porphyromonas gingivalis in juvenile idiopathic arthritis', Pediatric Rheumatology, vol. 14, no. 1, 8. https://doi.org/10.1186/s12969-016-0068-6
Lange, Lauren ; Thiele, Geoffrey Milton ; McCracken, Courtney ; Wang, Gabriel ; Ponder, Lori A. ; Angeles-Han, Sheila T. ; Rouster-Stevens, Kelly A. ; Hersh, Aimee O. ; Vogler, Larry B. ; Bohnsack, John F. ; Abramowicz, Shelly ; Mikuls, Ted R ; Prahalad, Sampath. / Symptoms of periodontitis and antibody responses to Porphyromonas gingivalis in juvenile idiopathic arthritis. In: Pediatric Rheumatology. 2016 ; Vol. 14, No. 1.
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abstract = "Background: The association between rheumatoid arthritis (RA) and periodontitis is well established. Some children with juvenile idiopathic arthritis (JIA) phenotypically resemble adults with RA, characterized by the presence of anti-cyclic citrullinated peptide (CCP) antibodies. We sought to investigate an association between CCP-positive JIA and symptoms of periodontitis and antibodies to oral microbiota. Methods: Antibodies to oral pathogens Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum were measured using ELISA in 71 children with CCP-positive JIA and 74 children with CCP-negative JIA. Oral health history was collected from 37 children with CCP-positive JIA and 121 children with CCP-negative JIA. T-tests, Chi-square tests, Mann-Whitney U tests, and multivariable regression were used to compare the groups. Results: Compared to those with CCP-negative JIA, children with CCP-positive JIA were more likely to be female, older and non-Caucasian. Anti-P. gingivalis (p <0.003) and anti-P. intermedia (p <0.008) IgG antibody titers were higher in the CCP-positive cohort. Differences in P. gingivalis antibody titers remained significant after adjusting for age (p = 0.007). Children with CCP-positive JIA more likely reported tender/bleeding gums (43{\%} vs. 24{\%}, p < 0.02) compared to children with CCP-negative JIA. After controlling for age at collection, the odds of having tender/bleeding gums were 2.2 times higher in the CCP-positive group compared (95{\%} CI 0.98 - 4.83; p = 0.056). Conclusions: Children with CCP-positive JIA have higher antibody titers to P. gingivalis and more symptoms of poor oral health, supporting a possible role for periodontitis in the etiology of CCP-positive JIA.",
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AU - Lange, Lauren

AU - Thiele, Geoffrey Milton

AU - McCracken, Courtney

AU - Wang, Gabriel

AU - Ponder, Lori A.

AU - Angeles-Han, Sheila T.

AU - Rouster-Stevens, Kelly A.

AU - Hersh, Aimee O.

AU - Vogler, Larry B.

AU - Bohnsack, John F.

AU - Abramowicz, Shelly

AU - Mikuls, Ted R

AU - Prahalad, Sampath

PY - 2016/2/9

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N2 - Background: The association between rheumatoid arthritis (RA) and periodontitis is well established. Some children with juvenile idiopathic arthritis (JIA) phenotypically resemble adults with RA, characterized by the presence of anti-cyclic citrullinated peptide (CCP) antibodies. We sought to investigate an association between CCP-positive JIA and symptoms of periodontitis and antibodies to oral microbiota. Methods: Antibodies to oral pathogens Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum were measured using ELISA in 71 children with CCP-positive JIA and 74 children with CCP-negative JIA. Oral health history was collected from 37 children with CCP-positive JIA and 121 children with CCP-negative JIA. T-tests, Chi-square tests, Mann-Whitney U tests, and multivariable regression were used to compare the groups. Results: Compared to those with CCP-negative JIA, children with CCP-positive JIA were more likely to be female, older and non-Caucasian. Anti-P. gingivalis (p <0.003) and anti-P. intermedia (p <0.008) IgG antibody titers were higher in the CCP-positive cohort. Differences in P. gingivalis antibody titers remained significant after adjusting for age (p = 0.007). Children with CCP-positive JIA more likely reported tender/bleeding gums (43% vs. 24%, p < 0.02) compared to children with CCP-negative JIA. After controlling for age at collection, the odds of having tender/bleeding gums were 2.2 times higher in the CCP-positive group compared (95% CI 0.98 - 4.83; p = 0.056). Conclusions: Children with CCP-positive JIA have higher antibody titers to P. gingivalis and more symptoms of poor oral health, supporting a possible role for periodontitis in the etiology of CCP-positive JIA.

AB - Background: The association between rheumatoid arthritis (RA) and periodontitis is well established. Some children with juvenile idiopathic arthritis (JIA) phenotypically resemble adults with RA, characterized by the presence of anti-cyclic citrullinated peptide (CCP) antibodies. We sought to investigate an association between CCP-positive JIA and symptoms of periodontitis and antibodies to oral microbiota. Methods: Antibodies to oral pathogens Porphyromonas gingivalis, Prevotella intermedia, and Fusobacterium nucleatum were measured using ELISA in 71 children with CCP-positive JIA and 74 children with CCP-negative JIA. Oral health history was collected from 37 children with CCP-positive JIA and 121 children with CCP-negative JIA. T-tests, Chi-square tests, Mann-Whitney U tests, and multivariable regression were used to compare the groups. Results: Compared to those with CCP-negative JIA, children with CCP-positive JIA were more likely to be female, older and non-Caucasian. Anti-P. gingivalis (p <0.003) and anti-P. intermedia (p <0.008) IgG antibody titers were higher in the CCP-positive cohort. Differences in P. gingivalis antibody titers remained significant after adjusting for age (p = 0.007). Children with CCP-positive JIA more likely reported tender/bleeding gums (43% vs. 24%, p < 0.02) compared to children with CCP-negative JIA. After controlling for age at collection, the odds of having tender/bleeding gums were 2.2 times higher in the CCP-positive group compared (95% CI 0.98 - 4.83; p = 0.056). Conclusions: Children with CCP-positive JIA have higher antibody titers to P. gingivalis and more symptoms of poor oral health, supporting a possible role for periodontitis in the etiology of CCP-positive JIA.

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KW - Juvenile idiopathic arthritis

KW - Periodontitis

KW - Porphyromonas gingivalis

KW - Prevotella intermedia

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