Symptoms and quality of life in diverse patients undergoing hematopoietic stem cell transplantation

Marlene Z. Cohen, Cathy L. Rozmus, Tito R. Mendoza, Nikhil S. Padhye, Joyce Neumann, Ibrahima Gning, Ana Aleman, Sergio Giralt, Charles S. Cleeland

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Context: Symptoms and quality of life (QOL) are critically important in hematopoietic stem cell transplantation (HSCT). However, few studies have examined these factors by transplant type among diverse cultures. Objectives: To identify and compare QOL and symptom severity and prevalence by transplant type in a diverse population having HSCT. Methods: The M. D. Anderson Symptom Inventory Blood and Marrow Transplantation (MDASI-BMT) module measured symptom severity and its impact. The Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) measured QOL. Results: Symptom data were collected from 164 patients at eight points (pretransplant to 100 days post-transplant) and QOL data at four times. Over time, symptom severity was significantly correlated with QOL and patients who had allogeneic transplants with myeloablative regimens showed more severe sleep disturbance and poorer QOL than patients having autologous transplants. Male patients reported less fatigue than female patients. However, ethnicity was not significant. Patients whose functional status was good had fewer of the five worst symptoms and higher QOL than patients with a poor functional status. Patients with acute graft-versus-host disease had more severe symptoms than those who did not. Conclusion: Type of transplant and preparative regimen are the most important aspects to consider when managing symptoms and QOL. This information is important for providing anticipatory guidance and support needed during the transplantation experience, to explore in future research the mechanisms involved in symptoms after HSCT, and to develop additional effective interventions.

Original languageEnglish (US)
Pages (from-to)168-180
Number of pages13
JournalJournal of Pain and Symptom Management
Volume44
Issue number2
DOIs
StatePublished - Aug 2012

Fingerprint

Hematopoietic Stem Cell Transplantation
Quality of Life
Transplants
Transplantation
Bone Marrow
Bone Neoplasms
Autografts
Graft vs Host Disease
Fatigue
Sleep
Equipment and Supplies
Population

Keywords

  • Hematopoietic stem cell transplantation
  • ethnic diversity
  • quality of life
  • symptoms
  • transplant type

ASJC Scopus subject areas

  • Nursing(all)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Cohen, M. Z., Rozmus, C. L., Mendoza, T. R., Padhye, N. S., Neumann, J., Gning, I., ... Cleeland, C. S. (2012). Symptoms and quality of life in diverse patients undergoing hematopoietic stem cell transplantation. Journal of Pain and Symptom Management, 44(2), 168-180. https://doi.org/10.1016/j.jpainsymman.2011.08.011

Symptoms and quality of life in diverse patients undergoing hematopoietic stem cell transplantation. / Cohen, Marlene Z.; Rozmus, Cathy L.; Mendoza, Tito R.; Padhye, Nikhil S.; Neumann, Joyce; Gning, Ibrahima; Aleman, Ana; Giralt, Sergio; Cleeland, Charles S.

In: Journal of Pain and Symptom Management, Vol. 44, No. 2, 08.2012, p. 168-180.

Research output: Contribution to journalArticle

Cohen, MZ, Rozmus, CL, Mendoza, TR, Padhye, NS, Neumann, J, Gning, I, Aleman, A, Giralt, S & Cleeland, CS 2012, 'Symptoms and quality of life in diverse patients undergoing hematopoietic stem cell transplantation', Journal of Pain and Symptom Management, vol. 44, no. 2, pp. 168-180. https://doi.org/10.1016/j.jpainsymman.2011.08.011
Cohen, Marlene Z. ; Rozmus, Cathy L. ; Mendoza, Tito R. ; Padhye, Nikhil S. ; Neumann, Joyce ; Gning, Ibrahima ; Aleman, Ana ; Giralt, Sergio ; Cleeland, Charles S. / Symptoms and quality of life in diverse patients undergoing hematopoietic stem cell transplantation. In: Journal of Pain and Symptom Management. 2012 ; Vol. 44, No. 2. pp. 168-180.
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