SWATH-MS proteome profiling data comparison of DJ-1, Parkin, and PINK1 knockout rat striatal mitochondria

Kelly L. Stauch, Lance M. Villeneuve, Phillip R. Purnell, Sanjit Pandey, Chittibabu Guda, Howard S Fox

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This article reports changes in the striatal non-synaptic mitochondrial proteome of DJ-1, Parkin, and PINK1 knockout (KO) rats at 3 months of age. DJ-1, Parkin, and PINK1 mutations cause autosomal-recessive parkinsonism. It is thought that loss of function of these proteins contributes to the onset and pathogenesis of Parkinson׳s disease (PD). As DJ-1, Parkin, and PINK1 have functions in the regulation of mitochondria, the dataset generated here highlights protein expression changes, which can be helpful for understanding pathological mitochondrial alterations. In total, 1281 proteins were quantified and 25, 37, and 15 proteins were found to exhibit differential expression due to DJ-1, Parkin, and PINK1 deficiency, respectively. All quantification can be found in the supplemental table and can be searched online at http://genome.unmc.edu/mitorat/index.html. Further, mitochondrial respiration was measured to evaluate mitochondrial function in the striatum of DJ-1, Parkin, and PINK1 KO rats, which was significantly changed only in the DJ-1 KOs.

Original languageEnglish (US)
Pages (from-to)589-593
Number of pages5
JournalData in Brief
Volume9
DOIs
StatePublished - Dec 1 2016

Fingerprint

Corpus Striatum
Proteome
Mitochondria
Proteins
Parkinsonian Disorders
Parkinson Disease
Respiration
Genome
Mutation

Keywords

  • Mitochondria
  • Parkinson׳s disease
  • SWATH-MS

ASJC Scopus subject areas

  • General

Cite this

SWATH-MS proteome profiling data comparison of DJ-1, Parkin, and PINK1 knockout rat striatal mitochondria. / Stauch, Kelly L.; Villeneuve, Lance M.; Purnell, Phillip R.; Pandey, Sanjit; Guda, Chittibabu; Fox, Howard S.

In: Data in Brief, Vol. 9, 01.12.2016, p. 589-593.

Research output: Contribution to journalArticle

Stauch, Kelly L. ; Villeneuve, Lance M. ; Purnell, Phillip R. ; Pandey, Sanjit ; Guda, Chittibabu ; Fox, Howard S. / SWATH-MS proteome profiling data comparison of DJ-1, Parkin, and PINK1 knockout rat striatal mitochondria. In: Data in Brief. 2016 ; Vol. 9. pp. 589-593.
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