Suzuki-Miyaura coupling with high turnover number using an N-acyl-N-heterocyclic carbene palladacycle precursor

Hector Palencia, Federico Garcia-Jimenez, James M. Takacs

Research output: Contribution to journalArticle

54 Scopus citations


A simple N-acylimidazolium salt precursor to a NHC-complexed palladacyclic ligand gives high turnover numbers (107) for Suzuki-Miyaura coupling and is applied to the preparation of biaryls used in the synthesis of coumarins. The results suggest that N-acyl-NHC derivatives can contribute to further expanding the rich chemistry of NHCs.

Original languageEnglish (US)
Pages (from-to)3849-3853
Number of pages5
JournalTetrahedron Letters
Issue number20
Publication statusPublished - May 10 2004



  • Biaryls
  • Catalysis
  • Coumarin synthesis
  • N-Acyl-N-heterocyclic carbene
  • N-Heterocyclic carbene ligand
  • NHC
  • Palladium catalyst
  • Suzuki-Miyaura coupling

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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