Abstract
Antiretroviral drug therapy (ART) effectively suppresses replication of both the immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon after ART is withdrawn. SIV-infected monkeys were treated with a 90-day course of ART initiated at 5 weeks post infection followed at 9 weeks post infection by infusions of a primatized monoclonal antibody against the α4β7 integrin administered every 3 weeks until week 32. These animals subsequently maintained low to undetectable viral loads and normal CD4+ T cell counts in plasma and gastrointestinal tissues for more than 9 months, even after all treatment was withdrawn. This combination therapy allows macaques to effectively control viremia and reconstitute their immune systems without a need for further therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 197-202 |
| Number of pages | 6 |
| Journal | Science |
| Volume | 354 |
| Issue number | 6309 |
| DOIs | |
| State | Published - Oct 14 2016 |
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ASJC Scopus subject areas
- General
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Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy. / Byrareddy, Siddappa Nagadenahalli; Arthos, James; Cicala, Claudia; Villinger, Francois; Ortiz, Kristina T.; Little, Dawn; Sidell, Neil; Kane, Maureen A.; Yu, Jianshi; Jones, Jace W.; Santangelo, Philip J.; Zurla, Chiara; McKinnon, Lyle R.; Arnold, Kelly B.; Woody, Caroline E.; Walter, Lutz; Roos, Christian; Noll, Angela; Van Ryk, Donald; Jelicic, Katija; Cimbro, Raffaello; Gumber, Sanjeev; Reid, Michelle D.; Adsay, Volkan; Amancha, Praveen K.; Mayne, Ann E.; Parslow, Tristram G.; Fauci, Anthony S.; Ansari, Aftab A.
In: Science, Vol. 354, No. 6309, 14.10.2016, p. 197-202.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy
AU - Byrareddy, Siddappa Nagadenahalli
AU - Arthos, James
AU - Cicala, Claudia
AU - Villinger, Francois
AU - Ortiz, Kristina T.
AU - Little, Dawn
AU - Sidell, Neil
AU - Kane, Maureen A.
AU - Yu, Jianshi
AU - Jones, Jace W.
AU - Santangelo, Philip J.
AU - Zurla, Chiara
AU - McKinnon, Lyle R.
AU - Arnold, Kelly B.
AU - Woody, Caroline E.
AU - Walter, Lutz
AU - Roos, Christian
AU - Noll, Angela
AU - Van Ryk, Donald
AU - Jelicic, Katija
AU - Cimbro, Raffaello
AU - Gumber, Sanjeev
AU - Reid, Michelle D.
AU - Adsay, Volkan
AU - Amancha, Praveen K.
AU - Mayne, Ann E.
AU - Parslow, Tristram G.
AU - Fauci, Anthony S.
AU - Ansari, Aftab A.
PY - 2016/10/14
Y1 - 2016/10/14
N2 - Antiretroviral drug therapy (ART) effectively suppresses replication of both the immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon after ART is withdrawn. SIV-infected monkeys were treated with a 90-day course of ART initiated at 5 weeks post infection followed at 9 weeks post infection by infusions of a primatized monoclonal antibody against the α4β7 integrin administered every 3 weeks until week 32. These animals subsequently maintained low to undetectable viral loads and normal CD4+ T cell counts in plasma and gastrointestinal tissues for more than 9 months, even after all treatment was withdrawn. This combination therapy allows macaques to effectively control viremia and reconstitute their immune systems without a need for further therapy.
AB - Antiretroviral drug therapy (ART) effectively suppresses replication of both the immunodeficiency viruses, human (HIV) and simian (SIV); however, virus rebounds soon after ART is withdrawn. SIV-infected monkeys were treated with a 90-day course of ART initiated at 5 weeks post infection followed at 9 weeks post infection by infusions of a primatized monoclonal antibody against the α4β7 integrin administered every 3 weeks until week 32. These animals subsequently maintained low to undetectable viral loads and normal CD4+ T cell counts in plasma and gastrointestinal tissues for more than 9 months, even after all treatment was withdrawn. This combination therapy allows macaques to effectively control viremia and reconstitute their immune systems without a need for further therapy.
UR - http://www.scopus.com/inward/record.url?scp=84991712477&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84991712477&partnerID=8YFLogxK
U2 - 10.1126/science.aag1276
DO - 10.1126/science.aag1276
M3 - Article
C2 - 27738167
AN - SCOPUS:84991712477
VL - 354
SP - 197
EP - 202
JO - Science
JF - Science
SN - 0036-8075
IS - 6309
ER -