Susceptibilities of oral bacteria and yeast to mammalian cathelicidins

J. M. Guthmiller, K. G. Vargas, R. Srikantha, L. L. Schomberg, P. L. Weistroffer, Jr McCray, B. F. Tack

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

The effects of cathelicidins against oral bacteria and clinically important oral yeasts are not known. We tested the susceptibilities of Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus sanguis, Candida krusei, Candida tropicalis and Candida albicans to the following cathelicidins: FALL39, SMAP29, and CAP18. SMAP29 and CAP18 were antimicrobial, whereas FALL39 did not exhibit antimicrobial activity. Future studies are needed to determine the potential use of these antimicrobial peptides in prevention and treatment of oral infections.

Original languageEnglish (US)
Pages (from-to)3216-3219
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number11
DOIs
StatePublished - Nov 1 2001

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Cathelicidins
Yeasts
Streptococcus sanguis
Fusobacterium nucleatum
Candida tropicalis
Bacteria
Aggregatibacter actinomycetemcomitans
Porphyromonas gingivalis
Candida albicans
Candida
Peptides
Infection
CAP18 lipopolysaccharide-binding protein

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Guthmiller, J. M., Vargas, K. G., Srikantha, R., Schomberg, L. L., Weistroffer, P. L., McCray, J., & Tack, B. F. (2001). Susceptibilities of oral bacteria and yeast to mammalian cathelicidins. Antimicrobial Agents and Chemotherapy, 45(11), 3216-3219. https://doi.org/10.1128/AAC.45.11.3216-3219.2001

Susceptibilities of oral bacteria and yeast to mammalian cathelicidins. / Guthmiller, J. M.; Vargas, K. G.; Srikantha, R.; Schomberg, L. L.; Weistroffer, P. L.; McCray, Jr; Tack, B. F.

In: Antimicrobial Agents and Chemotherapy, Vol. 45, No. 11, 01.11.2001, p. 3216-3219.

Research output: Contribution to journalArticle

Guthmiller, JM, Vargas, KG, Srikantha, R, Schomberg, LL, Weistroffer, PL, McCray, J & Tack, BF 2001, 'Susceptibilities of oral bacteria and yeast to mammalian cathelicidins', Antimicrobial Agents and Chemotherapy, vol. 45, no. 11, pp. 3216-3219. https://doi.org/10.1128/AAC.45.11.3216-3219.2001
Guthmiller, J. M. ; Vargas, K. G. ; Srikantha, R. ; Schomberg, L. L. ; Weistroffer, P. L. ; McCray, Jr ; Tack, B. F. / Susceptibilities of oral bacteria and yeast to mammalian cathelicidins. In: Antimicrobial Agents and Chemotherapy. 2001 ; Vol. 45, No. 11. pp. 3216-3219.
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