Survival of the fittest: Overcoming oxidative stress at the extremes of acid, heat and metal

Yukari Maezato, Paul Blum

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

The habitat of metal respiring acidothermophilic lithoautotrophs is perhaps the most oxidizing environment yet identified. Geothermal heat, sulfuric acid and transition metals contribute both individually and synergistically under aerobic conditions to create this niche. Sulfuric acid and metals originating from sulfidic ores catalyze oxidative reactions attacking microbial cell surfaces including lipids, proteins and glycosyl groups. Sulfuric acid also promotes hydrocarbon dehydration contributing to the formation of black "burnt" carbon. Oxidative reactions leading to abstraction of electrons is further impacted by heat through an increase in the proportion of reactant molecules with sufficient energy to react. Collectively these factors and particularly those related to metals must be overcome by thermoacidophilic lithoautotrophs in order for them to survive and proliferate. The necessary mechanisms to achieve this goal are largely unknown however mechanistics insights have been gained through genomic studies. This review focuses on the specific role of metals in this extreme environment with an emphasis on resistance mechanisms in Archaea.

Original languageEnglish (US)
Pages (from-to)229-242
Number of pages14
JournalLife
Volume2
Issue number3
DOIs
StatePublished - Aug 23 2012

Fingerprint

Extreme Heat
Oxidative stress
Oxidative Stress
sulfuric acid
oxidative stress
Metals
metals
heat
acids
Acids
acid
metal
transition elements
Soot
Hot Temperature
transition element
aerobic conditions
Archaea
Hydrocarbons
oxic conditions

Keywords

  • Archaea
  • Ecology
  • Metals
  • Natural habitats
  • Oxidative stress

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Space and Planetary Science
  • Palaeontology

Cite this

Survival of the fittest : Overcoming oxidative stress at the extremes of acid, heat and metal. / Maezato, Yukari; Blum, Paul.

In: Life, Vol. 2, No. 3, 23.08.2012, p. 229-242.

Research output: Contribution to journalReview article

@article{5cb9aaf84a7e4f39ae32d3f995daf480,
title = "Survival of the fittest: Overcoming oxidative stress at the extremes of acid, heat and metal",
abstract = "The habitat of metal respiring acidothermophilic lithoautotrophs is perhaps the most oxidizing environment yet identified. Geothermal heat, sulfuric acid and transition metals contribute both individually and synergistically under aerobic conditions to create this niche. Sulfuric acid and metals originating from sulfidic ores catalyze oxidative reactions attacking microbial cell surfaces including lipids, proteins and glycosyl groups. Sulfuric acid also promotes hydrocarbon dehydration contributing to the formation of black {"}burnt{"} carbon. Oxidative reactions leading to abstraction of electrons is further impacted by heat through an increase in the proportion of reactant molecules with sufficient energy to react. Collectively these factors and particularly those related to metals must be overcome by thermoacidophilic lithoautotrophs in order for them to survive and proliferate. The necessary mechanisms to achieve this goal are largely unknown however mechanistics insights have been gained through genomic studies. This review focuses on the specific role of metals in this extreme environment with an emphasis on resistance mechanisms in Archaea.",
keywords = "Archaea, Ecology, Metals, Natural habitats, Oxidative stress",
author = "Yukari Maezato and Paul Blum",
year = "2012",
month = "8",
day = "23",
doi = "10.3390/life2030229",
language = "English (US)",
volume = "2",
pages = "229--242",
journal = "Life",
issn = "0024-3019",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

TY - JOUR

T1 - Survival of the fittest

T2 - Overcoming oxidative stress at the extremes of acid, heat and metal

AU - Maezato, Yukari

AU - Blum, Paul

PY - 2012/8/23

Y1 - 2012/8/23

N2 - The habitat of metal respiring acidothermophilic lithoautotrophs is perhaps the most oxidizing environment yet identified. Geothermal heat, sulfuric acid and transition metals contribute both individually and synergistically under aerobic conditions to create this niche. Sulfuric acid and metals originating from sulfidic ores catalyze oxidative reactions attacking microbial cell surfaces including lipids, proteins and glycosyl groups. Sulfuric acid also promotes hydrocarbon dehydration contributing to the formation of black "burnt" carbon. Oxidative reactions leading to abstraction of electrons is further impacted by heat through an increase in the proportion of reactant molecules with sufficient energy to react. Collectively these factors and particularly those related to metals must be overcome by thermoacidophilic lithoautotrophs in order for them to survive and proliferate. The necessary mechanisms to achieve this goal are largely unknown however mechanistics insights have been gained through genomic studies. This review focuses on the specific role of metals in this extreme environment with an emphasis on resistance mechanisms in Archaea.

AB - The habitat of metal respiring acidothermophilic lithoautotrophs is perhaps the most oxidizing environment yet identified. Geothermal heat, sulfuric acid and transition metals contribute both individually and synergistically under aerobic conditions to create this niche. Sulfuric acid and metals originating from sulfidic ores catalyze oxidative reactions attacking microbial cell surfaces including lipids, proteins and glycosyl groups. Sulfuric acid also promotes hydrocarbon dehydration contributing to the formation of black "burnt" carbon. Oxidative reactions leading to abstraction of electrons is further impacted by heat through an increase in the proportion of reactant molecules with sufficient energy to react. Collectively these factors and particularly those related to metals must be overcome by thermoacidophilic lithoautotrophs in order for them to survive and proliferate. The necessary mechanisms to achieve this goal are largely unknown however mechanistics insights have been gained through genomic studies. This review focuses on the specific role of metals in this extreme environment with an emphasis on resistance mechanisms in Archaea.

KW - Archaea

KW - Ecology

KW - Metals

KW - Natural habitats

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=84894369857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894369857&partnerID=8YFLogxK

U2 - 10.3390/life2030229

DO - 10.3390/life2030229

M3 - Review article

C2 - 25371104

AN - SCOPUS:84894369857

VL - 2

SP - 229

EP - 242

JO - Life

JF - Life

SN - 0024-3019

IS - 3

ER -